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1 t • <br /> <br /> <br /> <br />IJ <br /> <br /> <br /> <br /> <br />~I <br /> <br />1 <br />1 <br /> <br /> <br /> <br /> <br /> <br />Table 5. Continued. <br />CYANIDE 43 <br />Species, dose, and <br />other variables E1Tects Reftrence• <br />Laboratory white rat, (continued) <br />Single intracarotid artery injection of KCN <br />1-2 mg/kg BW <br />2.5 mg/kg BW <br />3.5-5 mgfkg BW <br />Tissue residues 2.6-2.9 mg HCN/L <br />Inhalation exposure route, HCN vapor, in <br />mgfm3, for various periods <br />3,778 for 10 s <br />1,128 for 1 min <br />493 for 5 min <br />151-173 for 30-60 min <br />Single oral dose <br />3.4 mg KCN/kg BW <br />3.6-4.2 mg HCN/kg BR' <br />5.1-5.7 mg NaCN/kg BW <br />' 53 mg KCN/kg BW <br />- 6, 10, or 14 mg KCN/kg BW <br />6.4 mg NaCN/kg BW <br />7.5-10 mg KCN/kg Bbl' <br />8.6 mg KCN/kg BW <br />10 mg KCN/kg BW, equivalent <br />to 4 mg HCN/kg BW <br />Modest acute clinical <br />dysfunMion and incompVete <br />suppression of brain <br />el ectroencepha I ogre phic <br />(EEG) activity <br />Some deaths; survivors <br />showed rapid abolition of <br />brain EEG activity, 52°ro <br />reduction in brain cytochrome <br />oxidase activity, 600 increase <br />in lactate, 8550 decrease in <br />glycogen, 32"k reduction in <br />ATP, and 73~% increase in ADP; <br />all values returned to normal <br />in 6-24 h, end remained <br />normal for balance of 7-day <br />observation period <br />High incidence of <br />cardiovascular collapse <br />and death within minutes <br />Minimum lethal concentrations <br />in rats poisoned orally with <br />KCN <br />LC50 <br />LC50 <br />LC50 <br />LC50 <br />LD25 <br />LD50 <br />LD50 <br />LD50 <br />Some deaths in all groups; <br />a]] dead at higher doses <br />within 60 min; those killed 10 <br />min postadministration had <br />higher blood CN concentrations <br />than those killed near death <br />or at survival at 60 min <br />LD50 <br />LD50 <br />LD98 <br />LD50 <br />31 <br />31 <br />31 <br />1R <br />10 <br />10 <br />10 <br />1® <br />34 <br />lb <br />1Q <br />32 <br />13 <br />13 <br />10,13 <br />32 <br />20 <br />11 <br />1 <br />