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<br />' 44 BIOLOGICAL REPORT 85(1.23) <br /> Table 5. Continued. <br /> a <br />d <br />d <br />i <br /> n <br />ose, <br />es, <br />Spec <br /> other variables <br /> Laboratory white rat, (continued) <br /> 13.2 mg NaCN/kg BW or <br /> 7 mg HCN/kg BW <br /> <br />' 40 mg NaCN/kg BW, equivalent <br />to 21 mg HCN/kg BW <br /> Drinking water exposure <br /> Equivalent to 8 mg CN/kg BW <br />' daily for 21 days <br /> Equivalent to 21 mg CN/kg BW <br /> daily for 21 days <br /> 200 mg CN/L for 4 weeks <br />Drinking water of adults <br /> contained 150 mg CN(L, as <br /> KCN, for 2 weeks, followed <br /> by injection with <br /> radioselenium-75 and <br /> observed for 15 days <br />' Drinking water of weanling <br /> males contained 150 mg CN/L, <br /> for 9 weeks <br />' <br /> Dietary exposure <br /> Fed 12 mg CN/kg BR' daily for <br />' 2 years, equivalent to <br /> 300 mg HCN/kg ration <br />' Fed 500 mg HCN/kg ration to <br /> pregnant rats through <br /> gestation and lactation <br />' Weanlings fed diets of raw <br /> lime beans containing <br /> 727 mg CNlkg for 3 weeks, <br /> or 727 mg CN/kg diet as <br />' = <br />KCN for 3 weeks <br /> <br />' 750 mg CN/kg diet (1.875 mg <br />KCN/kg diet) for 8 weeks, <br />' adequate protein <br /> <br />Effects <br />Dead in 10.3 min; tissue <br />cyanide levels, in mg/kg FW, <br />were 8.9 in liver, 5.9 in <br />lung, 4.9 in blood, 2.1 in <br />spleen, and 1.5 in brain <br />Dead in 3.3 min <br />Liver normal <br />Significantly increased <br />liver weight <br />Reduced growth <br />Cyanide-treated rats excreted <br />significantly more <br />radioselenium in urine than <br />did controls; half-time <br />persistence of radioselenium <br />in treated group was 28 days <br />vs. 38 days in controls <br />Significant reduction in <br />glutathione activity, and <br />in selenium concentrations <br />in blood, kidney, liver, <br />and muscle <br />No measurable adverse effects <br />on blood chemistry, growth, <br />sunwal, or histology; <br />elevated thionanate levels <br />in liver end kidneys <br />No effect on reproduction <br />Lima bean diet alone <br />increased hepatic glutamate <br />dehydrogenase fGLDH/and <br />decreased isocitrate <br />dehydrngenaseflCDH) <br />activities; KCN diet <br />had no effect on GLDH end <br />increased ICDH activity, <br />emphasizing the importance <br />oC dietary components when <br />evaluating CN-containing <br />diets <br />No measurable effect on food <br />consumption or growth rate; <br />significantly increased serum <br />and urinary thiocyanate <br />concentrations <br />Reference <br />33 <br />33 <br />20 <br />20 <br />34 <br />35 <br />35 <br />1 <br />20 <br />36 <br />37 <br />W <br />1 <br />