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1 <br />' 42 <br /> <br /> <br /> <br /> <br /> <br />BIOIAGICAL REPGRT 85(1.23) <br />Table 5. Continued. <br />Species, dose, and <br />other variables <br />Rabbit, (continued) <br />Single oral dose, NeCN, <br />10-15 mg/kg BW <br />Inhalation of HCN from <br />combustion of 20 g of <br />polvacrylonitrile <br />Interval between death and remove] of tissues <br />for analysis in rabbits killed by KCN <br />Brain <br />' Blood <br />' Lung <br /> <br /> <br />1 <br />Domestic sheep, Ouis arias <br />Intravenous orintraarterial <br />injection, fetal lambs 80~ <br />through gestation (120 days), <br />NeCN, 50-900 µg <br />Single intramuscular injection <br />of 10 mg KCN/kg BW <br /> <br /> Laboratory white rat, Rattas spp. <br />' Single intraperitoneal injection <br /> 0.1-10 mg CN/kg BW <br /> 5 mg NaCN or KCN/kg BW <br />' <br /> 5 mg KCN/kg BW <br /> <br /> Intravenous injection, <br />' constant infusion of <br /> 0.15--0.20 mg CN/Itg BW <br /> per min <br />1 <br />Effects <br />All deed in 14-30 min; <br />blood cyanide ranged between <br />3.7 and 5.4 mg/L <br />All dead in 12-16 min; <br />blood cyanide ranged between <br />1.6 and 3.1 mg/L <br />Concentrations dropped from <br />1.6 mg/kg FW immediately <br />after death to 1.2 in 1 day, <br />0.92 in 3 days, and 0.04 in <br />7 days <br />Residues, in mg/kg FW, were <br />5.7 immediately after death, <br />and 2.3 after 21 days <br />Cyanide concentrations <br />dropped from 2 mg/kg FW <br />just after death, to 0.8 <br />in 7 days <br />Slowing of fetal heart rate, <br />disruption of respiratory <br />movements, significant but <br />inconsistent changes in <br />arterial blood pressure <br />All dead within 17 min; <br />cyanide concentrations <br />postmortem, in mg/kg FW, <br />were 3.3 in blood, 1.5 <br />in plasma, 1.6 in serum, <br />1.4 in cerebrospinal fluid, <br />0.9 in brain grey matter, <br />and 1.0 in brain white matter <br />LD50 <br />50~ro decrease in brain <br />cytochrome oxidase activity <br />within 5-10 min <br />Reversible intracellular <br />metabolic changes including <br />acidosis and increased <br />lactate levels-typical <br />of cellular anoxia <br />LD50 in about 20 min. <br />Rapid progressive reduction <br />in cerebrocortical cytochrome <br />oxidase (cytochrome aas) <br />concomitant with increases <br />up to 2005 in cerebral <br />blood (low <br />References <br />24 <br />24 <br />25 <br />25 <br />25 <br />26 <br />3,10,27 <br />28 <br />14 <br />29 <br />30 <br />Y <br /> <br />