Laserfiche WebLink
<br /> <br /> <br />i 1 <br /> <br /> <br /> <br /> <br />LJ~ <br />i <br /> <br /> <br /> <br /> <br />Table 5. Continued. <br /> <br />Species, dose, and <br />other variables <br />Humans, (continued) <br />Whole blood, 2.6-3.1 mg <br />total CN per liter <br />Whole blood, 4-45 mg <br />total CN per liter <br />Whole body, 7 mg HCN/kg BW <br />Daily dietary intake of <br />15-31.5 mg hydrogen <br />cyanide from cassava <br />100 mg HCN/kg BW applied to <br />skin surface <br />Clothing inundated with lO rt~ <br />NaCN solution, pH 11.4 <br />Livestock <br />>200 mg HCN/kg plant materials <br />in diet <br />Cvnomolgus monkeys, Macaca spp. <br />Given multiple sublethal doses <br />of KCN (5-16 mg) for 23 days <br />Exposed to HCN gas produced <br />from combustion of polyacrylonitrile <br />materials at various temperatures <br />300° C, 87-170 mg HCN/L air <br />600° C, 120-174 mg HCN/L air <br />900° C, 166-196 mg HCN/L air <br />Exposed to HCN gas at air <br />concentrations of 60. 80, or <br />150 mg HCN/L for 30 min <br />' = Exposed to HCN gas at air <br />concentrations of 100, 102, <br />123, 147, or 156 mg HCN/L air <br />1 <br /> <br /> Domestic mouse, Mus spp. <br /> Single intraperi tonea] injection <br /> HCN, 2.8 mg/kg BW <br /> NaCN, 4.6-5.9 mg/kg BW <br /> <br />CYANIDE 39 <br />Effects References <br />Minimum cyanide concentration 13 <br />associated with death in en <br />otherwise healthy individual <br />Levels measured in known 1$ <br />suicides <br />Residue associated with 11 <br />minimum lethal dose <br />Mantakessa disease-see text 15 <br />for discussion <br />LD50 11 <br />Clinical signs of toxicity 18 <br />within 25 min end death in <br />about 60 min <br />Potentially dangerous 18 <br />Brain histopathology 8 <br />]ncapacitated in 16-30 16 <br />min; blood cyanide of 4.3 mg/L <br />Incapacitated between 6 and 24 16 <br />min, blood cyanide of 2.96 mg/L <br />Incapacitated between 2 end 13 16 <br />min; blood cyanide <br />concentration of 3.1 mg/L <br />At 60 mg/L, HCN had only a 17 <br />slight depressive effect on <br />the central nervous system; <br />at 80 and 150 mg/L, severe CNS <br />depression and incapacitation <br />occurred <br />Incapacitated in 8 min at 16 <br />higher doses to 19 min at <br />lowest dose tested; blood <br />cvanide after 30 min <br />exposure ranged between <br />1.7 mg/L at 100 mg HCN/L and <br />3.2 mg/L at 156 mg HCN/L; <br />after recovery for 60 min, <br />blood CN ranged between 2.0 <br />and 2.9 mg/L <br />LD50 ]0 <br />LD50 10 <br />y <br />