1992-04-02_REVISION - M1988112 - Laserfiche WebLink

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1 1 1 1 r t 1 r 38 BIOLOGICAL REPORT 85(1.23) Table 5. Continued, Species, dose, and other variables Effects Reference' Humans, (continued) in mg/kg FW, were 0.3-1.] in blood, 0.3-1.0 in liver, and 0.2-0.3 in brain Found deed, four cases, time Maximum cyanide concentration to death unknown in stomach was 230 mg; maximum tissue residues, in mg/kg FW were 3.5 in blood, 6.3 in liver, and 0.5 in brain Attempted suicide by Severe tremors and progressive 39-year-old male, unknown ]oss of muscle amount of NaCN tone-representing the first case of cyanide intoxication with delayed onset of symptoms Inhalation of HCN gas, in mg/ms, for various time intervals 140 for 60 min Calculated LC50 220 for 30 min Calculated LC50 504 for !0 min Calculated LC50 680 for 5 min Calculated LC50 1,500 for 3 min Calculated LC50 4,400 for 1 min Calculated LC50 Inhalation of 2,000 mg HCN/L First breath results in deep, rapid breathing, with collapse, convulsions, and death within 1 min Inhalation of cyanogen chloride, in mg/L, for various time intervals 1, 10 min Irritant 48,30 min Fata] 159, 10 min Fata] Inhalation of cyanogen bromide, in mg/L, for various time intervals 1.9, no time given Irritant to eyes and nose ' 92, 10 min Fatal Single oral dose 0.5-3.5 mg HCN/kg BW Lethal 0.7-3.5 mg KCN/kg BW, Fatal equivalent io 50 to 250 mg KCN/adult 2 mg HCN/kg BW, or total of Acute LD50 for adults about 150 mg HCN I-5 g of NaCN or KCN, Minimum ]etha] dose equivalent to 0.2 g/adult or 3 mg/kg BNB Tissue residues Whole blood, I-Z mg free Usually lethal cyanide per liter 8 9 ld 10 1D 10 iD 1D 11 1 1 1 1 1 12,41 1D 13 14 42