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<br /> 40 <br /> <br />1 <br /> <br />B1OI.OCICAL REPORT 85(1.23) <br />Table 5. Continued. <br /> <br />Species, dose, end <br />other variables <br />Effects <br />Rekrence• <br />' Domestic Mouse, (contirsued) <br /> KCN, 5.3-6.7 mg/kg BW <br /> Acet„ne cyanohydrin, <br />' (CHahC(OH)CN, 8.7 mg/kg BW <br /> Malonitrile, NCCHsCN, <br /> 18 mg/kg BW <br /> Propionitrile, CHsCHzCN, <br /> 28 mg/kg BW <br /> N-butyronitrile, <br /> 38 mg/kg BW <br /> Acrylonitrile, CHzCHCN, <br /> 46 mg/kg BW <br /> Succinonitrile, <br /> NCCHzCHsCN, 62 mg/kg BW <br />' Acetonitrile, CHaCN, <br /> 175 mg/kg BW <br /> Single subcutaneous injection <br />HCN, 7.8-12.0 mg/kg BW <br /> KCN, 10 mg/kg B W <br />1 <br /> <br /> <br />Single oral dose <br />8.5 mg KCN/kg BW, equivalent to <br />' 3.4 mg CN-/kg BW <br />Drinking water, 1.000 mg <br />KCN/L, exposure for 90 days <br />1 <br />Rabbit; Oryctolagus app. <br />' Isolated aorta strips, 0.00014 <br />µg NaCN/Lr140 µg2 <br /> <br />LD50 <br />LD50 i7 days); first death in <br />5 min <br />LD50 (7 days); first death in <br />4.8 h <br />LD50 (7 days); first death in <br />21h <br />LD50 (7 days); first death in <br />2.2 h <br />LD50 (7 days); first death in <br />2.3 h <br />LD50 f7 days); first death in <br />5.1 h <br />LD50 (7 days); first death in <br />7.1 h <br />LD50 <br />Loss of consciousness in <br />100`%x; blood ammonia ]evels <br />increased 2.5 times; brain amino <br />acid levels (i.e., leucine, <br />isoleucine,tyrosine, <br />phenylalanine)increased <br />by 1.5-3.0 times; alpha <br />ketaglutarate,at 500 mg/kg <br />BW by intraperitoneal <br />injection, completely <br />blocked the development <br />ofcyanide-induced loss <br />o(cansciousness and <br />hyperammonemia <br />LD50 <br />Marked inhibition of <br />cytochrome oxidase activity <br />in liver, brain, and blood; <br />increased cyanide <br />concentrations in all <br />tissues; inhibition of <br />rhodanese activity; <br />diminished labile sulfur <br />tissue levels <br />Small contractions measured <br />at lowest dose tested, ED50 <br />at 70 µglL, and maximum <br />response at 140 µg2; higher <br />doses up to 19 mg/L produced <br />relaxation <br />10 <br />18 <br />18 <br />18 <br />18 <br />L8 <br />18 <br />18 <br />10 <br />1B <br />10,2Q <br />93 <br />21 <br />r <br />t <br />