7092

• UCREFRP Catalog Number: 7092
• Author: Eisler, R.
• Title: Arsenic Hazards to Fish, Wildlife, and Invertebrates
• USFW Year: 1988.
• USFW - Doc Type: A Synoptic Review.
• Copyright Material: NO

Table 6. (continued)
Organism and arsenical
Effect
Referencea
Arsenic trioxide Air c2ncentrations of 28.5
mg/m for 4 hours daily on
days 9 to 12 of gestation
caused fetotoxic effects
and chromosomal damage to
liver cells by day 18; effects
included reduced survival,
impaired growth, retarded
limb ossification, and bone3
abnormalities. At 2.9 mg/m ,
a 9.9% decrease in fetal weight
was recorded; at 0.26 mg/m , a
3.1% decrease was measured.
Cacodylic acid Oral dosages of 400 to 600
mg/kg BW on days 7 to 16 of
gestation produces fetal mal-
formations (cleft palate), de-
layed skeletal ossification,
and fetal weight reduction.
Sodium arsenate Maximum tolerated doses in terms
of abortion or maternal death
over 24 hours in 18-day+9reg-
nant mice were 20 mg As /kg
BW, intraperitoneal route, and
50 mg/kg BW when administered
orally. Residue half-life was
about 10 hours regardless of route
of administration.
Sodium arsenite Fed 5 mg/kg diet for three genera-
tions: reduced litter size, but
outwardly normal.
Sodium arsenite LD-50 of 9.6 mg/kg BW, subcuta-
neous route; LD-90 (7 days post-
administration) of 11.3 mg/kg BW,
subcutaneous route.
Sodium arsenite LD-50 of 12 mg/kg BW intraperi-
toneal route. At 10 mg/kg BW,
damage to bone marrow and sperm.
Sodium cacodylate Single intraperitoneal injection
of 1,200 mg/kg BW during mid-
13
5
14
6
15
16
gestation results in increased rates
of fetal skeletal malformations. 5
67