7092

• UCREFRP Catalog Number: 7092
• Author: Eisler, R.
• Title: Arsenic Hazards to Fish, Wildlife, and Invertebrates
• USFW Year: 1988.
• USFW - Doc Type: A Synoptic Review.
• Copyright Material: NO

Table 6. (continued)
Organism and arsenical
Sodium arsenate
Hamster, Cricetus sp.
Arsenate
Calcium arsenate
Dimethylarsinate
Gallium arsenide
Sodium arsenate
Sodium arsenate
Sodium arsenite
Sodium cacodylate
Effect
Intraperitoneal injection of 0.2
mg/kg BW at age 2 months causes
deafness.
Referencea
Maternal dose of 5 mg As+5/kg
BW caused some fetal mortality,
but no malformations; higher
dose of 20 mg/kg BW caused
54% fetal deaths and malfor-
mations.
Pulmonary tumorogenicity demon-
strated 70 weeks after 15 intra-
tracheal weekly injections of
3 mg/kg BW.
50% growth reduction in Chinese
hamster ovary cells (CHOC) at
90 to 112 mg/1.
Single oral dose of 100 mg/kg
BW mostly (85%) eliminated in
5 days, usually in form of organo-
arsenicals; all tissue levels
<0.25 mg/kg.
Dosed intravenously on day 8 of
gestation: 2 mg/.kg BW had
no measurable effect; 8 mg/
kg BW produced increased in-
cidence of malformation and
resorption; 16 mg/kg BW
killed all embryos.
50% growth reduction in CHOC
at 2.25 mg/1.
Chinese hamster ovary cells
(CHOC) show 50% growth re-
duction at 0.3 mg/1.
Single intraperitoneal in-
jection of 900 to 1,000
mg/kg BW during midgestation
results in some maternal deaths,
and increased incidences of fetal
malformations.
6
3
8
9
10
6
9
9
5
64