7092

• UCREFRP Catalog Number: 7092
• Author: Eisler, R.
• Title: Arsenic Hazards to Fish, Wildlife, and Invertebrates
• USFW Year: 1988.
• USFW - Doc Type: A Synoptic Review.
• Copyright Material: NO

Table 6. (continued)
Organism and arsenical
Effect
Referencea
Methanearsonic acid,
CH3As0(OH)2
Monosodium methanearsonate
Sodium arsenite
Dog, Canis familiaris
Cacodylic acid
Methanearsonic acid
Sodium arsenite
Domestic goat, Capra sp.
Arsenic acid
Guinea pig, Cavia sp.
Arsanilic acid
Arsenic trioxide
Sodium arsanilate
daily for 3 weeks followed by
20 mg/kg BW daily for 5 to
6 weeks was lethal. Adverse
effects at 25 mg/kg BW daily
for 10 days.
Calves were anorexic in 3 to 6
days when fed diets containing
4,000 mg/kg.
10 mg/kg BW daily for 10 days
fatal.
Single oral dose of 1 to 4
grams fatal.
Single oral LD-50 value of 1,000
mg/kg BW. Fed diets containing
30 mg/kg for 90 days with no
ill effects.
Fed diets containing 30 mg/kg
for 90 days with no ill effects
50 to 150 mg fatal.
Single oral dose of 2.5 to 7.5
mg/kg BW (50 to 150 mg)
was acutely toxic.
Dietary levels of 350 mg/kg
resulted in blindness and
optic disc atrophy in 25 to
30 days.
Fed diets containing 50 mg/kg
for 21 days; elevated As resi-
dues, in mg/kg fresh weight,
of 4 in blood, 15 in
spleen, and 20 in heart (vs.
<1 for all control tissues).
Subcutaneous injection of 70
mg/kg BW caused degeneration
of sensory walls of inner ear;
elevated As residues in cochlea.
5
5
3
3
5
5
3
3
6
7
6
63