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Table 6. Lethal and sublethal effects of various arsenicals on selected <br />species of mammals. <br />Organism and arsenical Effect Referencea <br />Cow, Bos bovis <br />Arsenate Cows fed 33 mg As+S daily per <br /> animal for 3 months had <br /> slightly elevated levels in <br /> muscle (0.02 mg/kg fresh <br /> weight vs. 0.005 in controls) <br /> and liver (0.03 vs. 0.012), <br /> but normal levels in milk <br /> and kidney. <br />+3 <br />Arsenate Cows fed 33 mg As <br />daily per <br /> animal for 15 to 28 months <br /> had tissue levels, in mg/kg <br /> fresh weight, of 0.002 for milk <br /> (vs. <0.001 for controls), <br /> 0.03 for muscle (vs. 0.005), <br /> 0.1 for liver (vs. 0.012), <br /> and 0.16 for kidney (vs. <br /> 0.053). <br />Cattle, Bos spp. <br />Arsenic pentoxide (wood Several deaths after eating <br />ashes treated with As wood ashes (780 mg/kg dry <br />preservative) weight); tissue residues, in <br /> mg As/kg fresh weight, of 13.9 <br /> in liver, 23.7 in kidney, and <br /> 25.8 in rumen contents (vs. <br /> normal values of <0.5). <br />Arsenic trioxide Single oral dose of 15 to <br /> 45 grams/animal fatal. <br />Arsenic trioxide Toxic dose is 33 to 55 <br /> mg/kg body weight (BW), <br /> or 13.2 to 22 grams for a <br /> 400 kg animal. Animals acci- <br /> dentally poisoned topically <br /> contained up to 15 mg As/kg <br /> fresh weight liver, 23 in <br /> kidney, and 45 in urine (vs. <br /> <1 for all normal tissues). <br />Cacodylic acid, Calves were anorexic in 3 to <br />(CH3)2As0(OH) 6 days when fed diets con- <br /> taining 4,700 mg/kg. Adult <br /> oral dosages of 10 mg/kg BW <br />4 <br />62