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PAGE: 3
<br />DATE: 12/05/89 ACCT: 535679-O1
<br />INDEX: 02893320096 CAT NO: 13620802 PO NBR: VERBAL GREG 11/28/89
<br />' CORROSIVE,
<br />ACUTE EXPOSURE- CONTACT MAY CAUSE DISINTEGRATION AND SLOUGHING OF
<br />CONJUNCTIVAL AND CORNEAL EPITHELIUM, CORNEAL OPACIFICATION, MARKED EDEMA
<br />AND ULCERATION, AFTER 7 TO 13 DAYS EITHER GRADUAL RECOVERY BEGINS OR THERE
<br />IS PROGRESSION OF ULCERATION AND CORNEAL OPACIFICATION, COMPLICATIONS OF
<br />SEVERE EYE BURNS ARE SYMBLEPHARON WITH OVERGROWTH OF THE CORNER BY A
<br />VgSCULRRIZED MEMBRANE, PROGRESSIVE OR RECURRENT CORNEAL ULCERATION AND
<br />PERMANENT CORNEAL OPACIFICATION, BLINDNESS MAY OCCUR,
<br />CHRONIC EXPOSURE- EFFECTS ARE DEPENDENT UPON .CONCENTRATION AND DURATION
<br />OF EXPOSURE, CONJUNCTIVITIS OR EFFECTS SIMILAR TO THOSE FOR ACUTE EXPOSURE
<br />MAY OCCUR.
<br />FIRST AID- WASH EYES IMMEDIATELY WITH LARGE AMOUNTS OF WATER, OCCRSIONALLY '
<br />LIFTING UPPER AND LOWER LIDS, UNTIL NO EVIDENCE OF CHEMICAL REMAINS (AT
<br />(EAST 15-20 MINUTES), CONTINUE IRRIGATING WITH NORMAL SALINE UNTIL THE PH
<br />HAS RETURNED TO NORMAL (30-60 MINUTES), COVER WITH STERILE BANDAGES, GET
<br />MEDICAL A7TENTION IMMEDIATELY.
<br />INGESTION:
<br />SODIUM HYDROXIDE:
<br />CORROSIVE/TOXIC,
<br />ACUTE EXPOSURE- THE REPORTED LETHAL DOSE IN RgTS IS 14-0-34-0 MG/KG,
<br />INGESTION MAY CAUSE A BURNING SENSATION IN THE MOUTH, CORROSION OF
<br />THE LIPS, MOUTH, TONGUE. AND PHARYNX, AND SEVERE ESOPHAGEAL
<br />AND ABDOMINAL PAIN, VOMITING OF BLOOD AND LARGE PIECES OF MUCOSA, AND
<br />BLOODY DIARRHEA, ASPHYXIA CAN OCCUR FROM SWELLING OF THE THROAT,
<br />MEDIASTINITIS, ALKALEMIA, PALLOR, NEAK, SLOW PULSE, CARDIOVASCULAR
<br />COLLAPSE, SHOCK, COMA AND DEATH MAY OCCUR, PERFORATION OF THE ALIMENTARY
<br />TRACT AND CONSTRICTIVE SCARRING MAY RESULT, ESOPHAGEAL STRICTURE MAY OCCUR
<br />REEKS, MONTHS, OR EVEN YEARS LATER TO MgKE SWALLOWING DIFFICULT, THE
<br />ESTIMATED FATAL DOSE IN MAN IS S GRAMS, CASES OF SQUAMOUS CELL CARCINOMA
<br />OF THE ESOPHAGUS HAVE OCCURRED WITH LATENT PERIODS OF 12 TO 4.2 YEARS AFTER
<br />INGESTION, THESE CANCERS WERE BELIEVED TO BE SEDUELA OF TISSUE DESTRUCTION
<br />AND POSSIBLY SCAR FORMATION RATHER THAN THE RESULT OF DIRECT CARCINOGENIC
<br />ACTION OF SODIUM HYDROXIDE,
<br />CHRONIC EXPOSURE- DEPENDING ON THE CONCENTRATION, REPEATED INGESTION OF
<br />ALKALINE SUBSTANCES MAY RESULT IN INFLAMMATORY AND ULCERATIVE EFFECTS ON
<br />THE ORAL MUCOUS MEMBRANES AND OTHER EFFECTS AS WITH ACUTE INGESTION,
<br />FIRST AID- ^ILUTE THE ALKALI BY GIVING WATER OR MILK IMMEDIATELY AND ALLOW
<br />VOMITING TO OCCUR, AVOID GASTRIC LAVAGE OR EMETICS, ESOPHAGOSCOPY IS THE
<br />ONLY WRY TO EXCLUDE THE POSSIBLITY OF CORROSION IN THE UPPER
<br />GASTROINTESTINAL TRACT; IF CORROSION IS SUSPECTED, ESOPHAGOSCOPY SHOULD
<br />USUALLY BE PERFORMED NITHIN 24~ HOURS CDREISBACH, HANDBOOK OF POISONING,
<br />12TH ED,~, MAINTAIN AIRWAY AND TREAT SHOCK, IF VOMITING OCCURS, KEEP HEAD
<br />BELOW HIPS TO HELP PREVENT ASPIRATION, GET MEDICAL ATTENTION IMMEDIATELY,
<br />TIDOTE:
<br />NO SPECIFIC ANTIDOTE, TREAT SYMPTOMATICALLY AND SUPPORTIVELY,
<br />REACTIVITY
<br />REACTIVITY:
<br />REACTS EXOTHERMICALLY WITH WATER,
<br />INCOMPATIBILITIES:
<br />SODIUM HYDROYIDE:
<br />ACETALDEHYDE: MRY RESULT IN VIOLENT POLYMERIZATION,
<br />ACETIC ACID: MIXING IN CLOSED CONTAINER INCREASES TEMPERATURE AND PRESSURE,
<br />ACETIC ANHYDRIDE: MIXING IN A CLOSED CONTAINER INCREASES TEMPERATURE AND
<br />PRESSURE,
<br />ACIDS: MAY REACT VIOLENTLY,
<br />ACROLEIN: MAY RESULT IN AN EXTREMELY VIOLENT POLYMERIZATION,
<br />ACRYLONITRILE: MAY CAUSE VIOLENT POLYMERIZATION,
<br />ALLYL ALCOHOL + BENZENE SULFONYL CHLORIDE: P-OSSIHLE EXPLOSION HAZARD,i
<br />ALLYL CHLORIDE: HYDROLYZES,
<br />ALUMINUM: VIGOROUS REACTION.
<br />ALUMINUM, ARSENIC TRIOXIDE. ,SODIUM ARSENATE: MAY GENERATE FLAMMABLE HYDROGEN
<br />GAS,
<br />AMMONIA AND SILVER NITRATE: PRECIPITATION OF EXPLOSIVE SIVLER NITRIDE MAY
<br />OCCUR,
<br />AMMONIUM SALTS: MAY REACT VIOLENTLY EVOLVING AMMONIA GAS,
<br />BENZENE-1, 'F-DIOL: EXOTHERMIC REACTION,
<br />N, N'-BIS(TRINITROETHYL)UREA: FORMATION OF EXPLOSIVE COMPOUND,
<br />BROMINE: POSSIBLE EXPLOSION IF NOT STIRRED CONTINOUSLY,
<br />CHLORINE TRIFLUORIDE: MAY CAUSE VIOLENT REACTION,
<br />CHLOROFORM AND METHYL ALCOHOL: EXOTHERMIC REACTION,
<br />CHLOROHYDRIN: MIXING IN A CLOSED CONTAINER CAUSES AN INCREASE. IN TEMPERATURE
<br />AND PRESSURE,
<br />4•-CHLORO-2-METHYLPHENOL: POSSIBLE IGNITION,
<br />CHLOR'ONITROTOLUENES: POSSIBLE EXPLOSION,
<br />CHLOROPICRIN: MAY CAUSE VIOLENT REACTION,
<br />CHLOROSULFONIC ACID: MIXING IN A CLOSED CONTAINER CRUSES AN INCREASE IN
<br />TEMPERATURE AND PRESSURE,
<br />CINNAMALDEHYDE: EXOTHERMIC REACTION,
<br />COATINGS: MAY BE ATTACKED,
<br />~YANOGEN AZIDE: MAY FORM SODIUM 5-AZIDOTETRAZOLIDE, WHICH IS EXPLOSIVE IF
<br />ISOLATED,
<br />2,2-DICHLORO-3,3-DIMETHYLBUTANE: HAZRRDOUS REACTION,
<br />~~
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