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PAGE: 2
<br />DATE: 12/05/89 ACCT: 535679-O1
<br />INDEX: 02893320096 CAT NO: 13620802 PO NBR: VERBAL GREG 11/28/89
<br />CORROSIVE MRTERIAL
<br />~PARTMENT OF TRANSPORTATION LABELING REDUIREMENTS 4.9CFR172,101 AND SUBPART E:
<br />RROSIVE
<br />DEPARTMENT OF TRANSPORTATION PACKAGING REQUIREMENTS: 49CFR173,2`f9
<br />EXCEPTIONS: `F9CFR173. 2't`4~
<br />TOXICITY
<br />SODIUM HYDROXIDE:
<br />IRRITATION DATA: 1'/-/2`h HOURS EYE-MONKEY SEVERE; 500 MG/2'h HOURS SKIN-RABBIT
<br />SEVERE; 1'/• EYE-RABBIT SEVERE; SD UG/2'h HOURS EYE-RABBIT SEVERE; 1 MG/2'F HOUR
<br />EYE-RABBIT SEVERE; 'h00 UG EYE-RABBIT MILD; 100 MG RINSED EYE-RABBIT SEVERE,
<br />TOXICITY DATA: 1`FO-3'h0 MG/KG ORAL-RAT LD50 (VAN WATERS & ROGERS INC. MSDS];
<br />500 MG/KG ORAL-RABBIT LDLO; 1350 MG/KG SKIN-RABBIT LD50 (VAN WATERS & ROGERS
<br />INC. MSDS]; `h0 MG/KG INTRAPERITONEAL-MOUSE LDSO; MUTAGENIC DATA (RTECS].
<br />CARCINOGEN STATUS: NONE,
<br />LOCAL EFFECTS: CORROSIVE- EYE, SKIN, MUCOUS MEMBRANES,
<br />ACUTE TOXICITY LEVEL: TOXIC BY INGESTION; MODERATELY TOXIC BY DERMAL
<br />ABSORPTION,
<br />TARGET EFFECTS: NO DATA AVAILABLE,
<br />HEALTH EFFECTS AND FIRST AID
<br />INHALATION:
<br />SODIUM HYDROXIDE:
<br />CORROSIVE, 250 MG/M3 IMMEDIATELY DANGEROUS TO LIFE OR HEALTH,
<br />ACUTE EXPOSURE- EFFECTS DUE TO INHALATION OF DUSTS OR MIST MAY VARY FROM
<br />MILD IRRITATION OF THE NOSE AT 2 MG/M3 TO SEVERE PNEUMONITIS DEPENDING
<br />O-N THE SEVERITY OF EXPOSURE, LOW CONCENTRATIONS MAY CAUSE MUCOUS MEMBRANE
<br />IRRITATION WITH SORE THROAT, COUGHING, AND DYSPNEA. INTENSE EXPOSURES MAY
<br />RESULT IN DESTRUCTION OF MUCOUS MEMBRANES ANO DELAYED PULMONARY EDEMA
<br />OR PNEUMONITIS, SHOCK MAY OCCUR,
<br />CHRONIC EXPOSURE- REPEATED EXPOSURES OF 5000 A1G/L HERE HARMLESS TO RATS,
<br />BUT 10,000 MG/L LED TO NERVOUSNESS, SORE EYES. DIARRHEA AND RETARDED
<br />GROWTH, PROLONGED EXPOSURE TO HIGH CONCENTRATIONS OF DUSTS OR MISTS
<br />MAY CAUSE DISCOMFORT AND ULCERATION OF NASAL PASSAGES, RATS EXPOSED
<br />30 MINUTES/DRY TO UNMEASURED CONCENTRATIONS OF SODIUM HYDROXIDE AEROSOLS
<br />SUFFERED PULMONARY DAMAGE AFTER 2-3 MONTHS, DEATH OCCURRED IN 2 OF 10 RATS
<br />EXPOSED TO AN AEROSOL OF 4-0'/. AQUEOUS SODIUM HYDROXIDE FOR 30 MINUTES,
<br />TWICE A WEEK FOR 3 WEEKS, HISTOPATHOLOGICAL EXAMINATION SHOWED MOSTLY
<br />NORMAL LUNG TISSUE WITH FOCI OF ENLARGED ALVEOLAR SEPTAE, EMPHYSEMA,
<br />BRONCHIAL ULCERATION, AND ENLARGED LYMPH ADENOIDAL TISSUES. AN
<br />EPIDEMIOLOGIC STUDY OF 291 WORKERS CHRONICALLY EXPOSED TO CAUSTIC DUSTS
<br />FOR 30 YEARS OR MORE FOUND NO SIGNIFICANT INCREASE IN MORTALITY IN
<br />RELATION TO DURATION OR INTENSITY OF SUCH EXPOSURES,
<br />FIRST RID- REMOVE FROM EXPOSURE AREA TO FRESH AIR IMMEDIATELY, IF BREATHING
<br />HAS STOPPED, GIVE ARTIFICIAL RESPIRATION, MAINTAIN.gIRWAY AND BLOOD
<br />PRESSURE AND ADMINISTER OXYGEN IF AVAILABLE, KEEP AFFECTED PERSON WARM AND
<br />AT REST, TREAT SYMPTOMATICALLY AND SUPPORTIVELY, ADMINISTRATION OF OXYGEN
<br />SHOULD BE PERFORMED BY QUALIFIED PERSONNEL, GET MEDICAL ATTENTION
<br />IMMEDIATELY_
<br />SKIN CONTACT:
<br />SODIUM HYDROXIDE:
<br />CORROSIVE,
<br />ACUTE EXPOSURE- UPON CONTACT WITH THE SKIN, DAMAGE INCLUDING REDNESS,
<br />CUTANEOUS BURNS, SKIN FISSURES AND WHITE ESCHARS MAY OCCUR WITHOUT
<br />IMMEDIATE PAIN, EXPOSURE TO SOLUTIONS AS WEAK AS 0, 03 N (0, 12'/•] FOR 1
<br />HOUR HAS CAUSED INJURY TO HEALTHY SKIN, SOLUTIONS OF 25-50'/- CAUSED ,NCO
<br />SENSATION OF IRRITATION WITHIN 3 MINUTES IN HUMAN SUBJECTS, WITH
<br />SOLUTIONS OF 0, 4~-'f'/_, IRRITATION DOES NOT OCCUR UNTIL AFTER SEVERAL HOURS,
<br />SKIN BIOPSIES FROM HUMAN SUBJECTS HAVING 1 N SODIUM HYDROXIDE APPLIED TO
<br />THEIR ARMS FOR 15 TO 180 MINUTES SHOWED PROGRESSIVE CHANGES BEGINNING
<br />WITH DISSOLUTION OF THE CELLS IN THE HORNY LAYER AND PROGRESSING
<br />THROUGH EDEMA TO TOTAL DESTRUCTION OF THE EPIDERMIS IN 60 MINUTES.
<br />A 5'/. AQUEOUS SOLUTION CAUSED SEVERE NECROSIS TO THE SKIN OF RABBITS
<br />NHEN APPLIED FOR 't HOURS, ALKALIES PENETRATE THE SKIN SLOHLY, THE EXTENT
<br />OF INJURY DEPENDS ON THE DURATION OF CONTACT, IF SODIUM HYDROXIDE IS NOT
<br />REMOVED FROM THE SKIN, SEVERE BURNS WITH DEEP ULCERATION MAY OCCUR,
<br />EXPOSURE TO THE DUST OR MIST MAY CRUSE MULTIPLE SMALL BURNS AND TEMPORARY
<br />LOSS OF HAIR, PATHOLOGIC FINDINGS DUE TO ALKALIES MAY INCLUDE GELATINOUS,
<br />NECROTIC AREAS AT THE SITE OF CONTACT,
<br />CHRONIC EXPOSURE- EFFECTS qRE DEPENDENT UPON CONCENTRATION AND DURATION
<br />OF EXPOSURE, DERMATITIS OR EFFECTS SIMILAR TO THOSE FOR ACUTE EXPOSURE
<br />MAY OCCUR,
<br />FIRST AID- REMOVE CONTAMINATED CLOTHING AND SHOES IMMEDIATELY, WASH AFFECTED
<br />AREA WITH SOgP OR MILD DETERGENT AND LARGE AMOUNTS OF WATER UNTIL NO
<br />EVIDENCE OF CHEMICAL REMAINS (AT LEAST 15-20 MINUTES], IN CASE OF CHEMICAL
<br />BURNS, COVER AREA WITH STERILE, DRY DRESSING, BANDAGE SECURELY, BUT NOT
<br />TOO TIGHTLY, GET MEDICAL ATTENTION IMMEDIATELY,
<br />E CONTACT:
<br />SODIUM HYDROXIDE:
<br />~~
<br />
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