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<br />MSD~~ -Diesel <br />Sinclair Oil Corporation -August 2000 <br />`~ <br />HAZARDOUS DECOMPOSITION: <br />Incomplete burning can produce carbon monoxide. <br />11. TOXICOLOGICAL INFORMATION <br />SYSTEMIC: <br />Petroleum-derived fuels and fuel oils are complex and vaziable mixtures of hydrocarbons. <br />In general; the more viscous the mixture, the less toxic it will be. At high level exposures, <br />humans experience multiple organ failur~:s, some of which may be due to hypoxia and <br />secondary to the failure of other organ systems. In humans kidney failure has been noted <br />only at high, acute levels of exposures, a1d appears reversible. Liver enzymes may be <br />transiently elevated. At tower level exposures, most acute health effects are reversible. <br />People can be exposed by inhalation, ingestion and dermal contact. Frequently, people are <br />exposed by combined dermal and inhalation exposure. <br />ACUTE: <br />Inhalation: Headaches, confusion, disorientation; blurred vision occur with inhalation. <br />Higher exposures may cause hallucinations, CNS excitation, drowsiness, CNS depression. <br />Seizure and coma occur from very high exposures and death may result from respiratory <br />depression. ECG ehangesti cardiac arrhyt:hmias, tachycardia, shock and cardiovascular <br />collapse can occur. Pneumonia, putmon.uy edema and hemorrhages can•occur. <br />Inhalation of 8000-1b000 mg/m3 far 2 tc 4 hours was lethal to rats: <br />ingestian: Central nervous system, cardiavaseuiaz, and respiratory effects have been <br />reported with acute exposures to various hydrocarbon fuels and oils similar to those <br />reported with inhalation. Nausea, vomiting, cramping and diarrhea may occur. <br />Eye: Conjunctivitis and burning, watery eyes have been reported in acute exposures to <br />various hydrocarbon fuels and oils. <br />Skin: Mild erythema to full thickness ch~.mical burns have occurred afrer prolonged <br />exposure to various hydrocarbon fuels and oils. <br />Chronic: <br />Chronic dermatitis with aeanthosis, inflammation, parakeratosis and hyperkeratosis have <br />occurred with chronic exposures to various hydrocarbon fuels and oils. <br />Occupational exposures in petroleum refining are considered Group 2A {probably <br />carcinogenic) by IARC. <br />Pagc 5 of 7 <br />