1992-04-02_REVISION - M1988112 - Laserfiche WebLink

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1 1 Table 4. Continued. Species, dose, and other variables Domestic chicken, (continued) Intravenous route (continued) 1.3 mg CN/kg BW, as KCN Inhalation route 0.12 mg HCN/L air Single oral dose, as NeCN 3.2 mg CN/kg BW, equivalent to 6.0 mg NaCN/kg BW 6.4 mg CN/kg BW 11,1 mg CN/kg BW 25.4 mg CN/kg B W Dietary route ' Fed cassava diets containing 4, 37, 70, or 103 mg total cyanide per kilogram ration to day-old chicks Cor 8 weeks ' Fed diets containing 135 mg HCN/kg Chicks, 20-day exposure ' Adults, 14-day exposure ' California condor, C,ymnogyps cali(ornianus Juvenile (9.4 kg), found dead, presumably of cyanide ' poisoning Eastern screech-owl, Otus asio 4.6 mg CN/kg BW, equivalent to 8.6 mg NaCN/kg BW ' Canary, Scrinus canarius 0.12 mg HCN/L air ~ - -- CYANIDE 31 Effects References Lethal 4 All survived Cor at least 60 min 2 No deaths in 30 min; 2 maximum CN levels, in mg/kg FW, were 1.1 in blood and 0.06 in liver Some deaths in 30 min; 2 maximum CN levels, in mg/kg FW were 1.6 in blood and 0.12 in liver Acute oral LD50; 95°c C.I. of 6.4 2 and 19.1 mg CN/kg BW Advanced signs of acute 2 poisoning; death probable within 30 min; maximum CN levels, in mg/kg FW, were 1.5 in blood and 0.6 in liver At all dietary levels, there 5 was no significant effect on survival, growth, histology, hemoglobin, hematocrit, or lymphocyte number; however, serum thiocyanate levels increased in adose-dependent manner Growth and food intake significantly depressed; plasma thiocyanate concentration increased Urinary excretion of thiocyanate increased 5 times in laying hens No evidence of injuries or disease; yellow Ouorescent particles found in mouth appeared like those placed in NaCN ejector mechanisms used in predator control. However, blood cyanide concentration was similar to that found in nonexposed vultures, including two captive California condors Acute oral LD50; 95 ~ C.1. of 3.8 and 5.4 mg CN/kg BW All dead in 3 min 6 6 2 2 2 Y