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MATERIAL SAFETY DATA SHEET
<br />Days to heal: 1
<br />Primary Irritaton Index (PII): 0.4/8,0
<br />Other effects: None.
<br />Essentia0y non initating.
<br />FIFRA category N.
<br />irtitation
<br />RabbR, 6 animals, OECD 405 test:
<br />Days to heal: 10
<br />Moderate Iritaton.
<br />FIFRA category II.
<br />Skin sensitlzatign
<br />Guinea pig, Buehler test:
<br />Positive incidence: 0 %
<br />FJ(PERIENCE WRH HUMAN EXPOSURE
<br />Ingestion, short teJm case re ort s
<br />Gastrointestinal effects: irritation, nausea/vomfling,
<br />diarrhea
<br />Ingestion. Short tet~m'
<br />Respiratory effects: increased fluid (n lungs
<br />(lumypulnanary oedema) '
<br />Cardiovascular effects: decreased blood pressure
<br />(hypotension)
<br />Similar formulation
<br />Acute oral tgxici
<br />Rat, LD50: 5,000 mg/kg hotly weight
<br />Sfigntty toxk.
<br />FIFRA category III.
<br />Acute dermal toxic
<br />Rabbit, LD50 (limit test): > 5,000 mg/kg body weight
<br />Precticalty non-toxic.
<br />FIFRA category N.
<br />No monaliry.
<br />Skin irritation
<br />Rab6R, 6 animals, OECD 404 test:
<br />Days to heal: 3
<br />Pdmary Irritation Index (PII): 7.0/8.0
<br />Slight in0a0ion.
<br />FIFRA category N.
<br />,E~e irtitation
<br />Rabbit, 6 animals ,OECD 405 test:
<br />Days ro heal: > 21
<br />D1her effects: pannus, tissue destmcibn in eye (necro-
<br />sis of conjunctivae)
<br />Severe imitation.
<br />FIFRA category I.
<br />Acute inhalation toxici
<br />Rat, LC50, 4 hours, aerosol: 3.28 rtg/L
<br />PrecticaAy non-toxk.
<br />FIFRA category IV.
<br />Skin sensitization
<br />Guinea pig, 9-Induction Buehler tesC
<br />Pos(ttve incidence: 0 %
<br />EXPERIENCE WRH HUMAN EXPOSURE
<br />Ingestion ¢xcessiv¢ intentional misuss
<br />Respiratory effects: pneumonitis {aspiration)
<br />Gastrointestinal effects: nauseaNOmking, diarrhea,
<br />abdominal pain, bloody vgmking (haematemes's)
<br />Cardiovascular effects: abnormal heart rhythm (ear-
<br />diac dysrhythmia), decreased heart ou7pN )myocardial
<br />depression)
<br />GeneraUsystemic effects: disturbances of fluid and
<br />elechoyte regulation, abnormalty tleueased blood vo4
<br />ume (hypovolaemia), elevated serum amylase, fluW
<br />bss (haemowncenlradon), no cholinesterase inhibL
<br />Uon
<br />Laboratory effects -blood chemistry: elevated
<br />serum transaminases, mild acidosis
<br />c~ta~t short term ep'demiologiral:
<br />Note: Ng cases of irreversible eye etteds could be
<br />aadbvled to glyptasate formulations N an extensive
<br />epitlemblogical survey gf reponed accidental eye mrv
<br />tad with Mese formulatiors.
<br />Niphosohonomethvllalvcine: {alvphosate)
<br />Mutaaenicity
<br />In vitro antl in vivo mutagenicity test(s):
<br />Nd mutagenic.
<br />Reoeated dose toxici
<br />Rabbit, dermal, 27 days:
<br />NOAEL toxiciy: > 5,000 mg/kg body weighllday
<br />Target organs/systems: None.
<br />Other efiecis: None.
<br />Rat, grel, 3 months:
<br />NOAEL toxiciy: > 20,000 mg/kg diet
<br />Target organs/systems : None.
<br />OMer effects: None.
<br />UPDATES AVAILABLE AT VVWW.GREENBOOK.NET 2.
<br />~~ Mouse, oral, 24 months:
<br />NOEL Nmour. > 30,000 mg/kg diet
<br />NOAEL toxicity:.-. 5,000 mg/kg diet
<br />Tumours: None.
<br />Target organs/systems: Ever
<br />OOar efreds: decrease of body weigh gain,
<br />hisfgpadrobgic eHacts
<br />Ral, oral, 24 months:
<br />NOEL tumour. > 20,000 mglkg tliet
<br />NOAEL toxiciy: ~ B,000 mg4cg diet
<br />Tumours: None.
<br />Target organs/systems: eyes
<br />OMer effects: decrease of body weght gab,
<br />histopathologic effects
<br />Toxic to reoroduction/fertillN
<br />Ral, oral, 3 generations:
<br />NOAEL toxiciy: > 30 mg/kg body weigh
<br />NOAEL reproductlon: > 30 mgrkg body weight
<br />Target organs/systems in parents: None.
<br />OMer effects in parents: None.
<br />Target organs/systems in pups: None.
<br />OMer effects in pups: None.
<br />Deveopmental toxidNlteratogenidty
<br />Rat, oral, 6 - 19 days of gestation:
<br />NOAEL toxiciy: 7.000 mg/kg body weigh
<br />NOAEL development 1,000 mg/kg body weight
<br />OMer effects in mother animal: decrease of body
<br />weight gain, decrease of survival
<br />Developmental effects: weight loss, post-implantation
<br />loss, delayed ossification
<br />Efrecis on offspring onty observed with maternal toxL
<br />chy.
<br />Rabble, oral, 6 - 27 days of gestation:
<br />NOAEL toxbiy: 175 mglkg Dotly weight
<br />NOAEL development t75 mglkg body weigh
<br />Target organs/systems in mother animal: None.
<br />OMer effects in mother animal: decrease of surv'wal
<br />Deveopmental effecs: None.
<br />72. ECOLOGICAL INFORMATION
<br />7ha section b intended for use by ecotoxicobgists and
<br />other environmental specialists.
<br />Monsanto has not conducted environmental studies
<br />on Mis product. Data obtainetl on similar products are
<br />summarized below.
<br />Similar formulation
<br />Aouatic toxici fish
<br />Bluegill sunfish (Lepomis macrochirus):
<br />Acute toxicity, 96 hours, flowihrough, LC50: 5.8 mg/L
<br />moderatey toxic
<br />Rainbow trout (Oncorhynchus myMiss):
<br />Acute toxbity, 9fi hours, flowlhrough, LC50: 8.2 mg/L
<br />motleratey toxic
<br />A, rru tic toxici invenebmtea
<br />Water flea (Daphnia magna):
<br />Acute toxicity, 48 hours, static, EC50: 72.9 ng/L
<br />slightty toxic
<br />Aauatic toxici algae/aquatic to anM '
<br />Green algae (Selenaatrum wpdcomutum):
<br />Acute toxicity, 96 hours, static, EC50: 2.6 mg1L
<br />moderatey toxic
<br />Avian toxic)
<br />Bobwhite quail (Colinus virginianus):
<br />Dietary toxicny, 5 days, LCSD: > 5,620 mg/kg diet
<br />pradicaly non-toxb
<br />Mafbrd duck (Arias platyrhynchos):
<br />Dietary toxicity, 5 days, LC:i0: > 5,620 mg/kg diet
<br />practicaly non-toxic
<br />Anhroood toxid
<br />Honey bee (Apia mellifere):
<br />OraVwntad. 48 hours, LD50: > 100 µglbee
<br />pradicaly ran-toxic
<br />Soil organism toxici invertebrates
<br />Earthworm (Eisenia foelida):
<br />Acute toxicity, 74 days, LC50: > 5,000 mg/kg dry soil
<br />pradicaly nomtoxic
<br />N-(phosphonomethviiglvcin¢; {glvohosate}
<br />Bioaccumulation
<br />Bluegill sunfish (Lepomis macrochirus):
<br />Whole fish: BCF: < 1
<br />No significant bioaccumulation is expected.
<br />Dissipation '
<br />Soil, field:
<br />HaH 1de: 2 - 174 days
<br />Kac: 884 -60,000 L1kg
<br />Binds strongy ro soil.
<br />Water, aerobic:
<br />Hatt life: < 7 days
<br />Identical rodud without reen dyg
<br />Biodegradation
<br />Zahn-Wellens test:
<br />Degredatbn: 80 % within 28 days
<br />Inherenity b'lodegradable.
<br />13. DISPOSAL CONSIDERATIONS
<br />Produp
<br />Dispose of as hazardous industrial waste.
<br />Recycle tt appropdate facilities/equipment available.
<br />Bum in special, wntrolletl high temperature incinere-
<br />tor,
<br />Keep out of drains, sewers, d4ches and water ways.
<br />Folow all bcaUreganaVnafionel regulatbrrs.
<br />Container '
<br />Triple rinse empty wntainers.
<br />Pour dose water into spray tank.
<br />Store for collectbn by approved waste disposal ser-
<br />vice.
<br />Dispose of as hazardous industrial waste.
<br />Do NOT reuse raMairlers.
<br />Follow all IocagregbnaVnationel regubtbns.
<br />14. TRANSPORT INFORMATION
<br />The data provided in this section is for information arty.
<br />Please appy the appropdate regulations ro properly
<br />Glassily your shipment for t2nsportatbn.
<br />Not hazardous under Me applicable DOT, ICAO/WTA,
<br />IMO, T'(Na' and Mexican regulators. '
<br />15. REGULATORY INFORMATION
<br />Database and format copyright ®by C6P Press. All rights reserved.
<br />t,
<br />-}F~ ~` i. - ..r
<br />y 3i;
<br />TSCA Inventory
<br />All wmponenis are on the US EPA's TSCA Inventory
<br />SARA Title III Rules
<br />Secton 3111312 HazaM Categories
<br />Immediate
<br />Section 302 Extremety Hazartlous Substances
<br />Not aDPliceble.
<br />Secton 373 Toxb Chembal(s)
<br />Not applicable.
<br />CERCLA Reportable quantity
<br />Not applicable.
<br />16. OTHER INFORMATION
<br />The information given here is rot necessariy exhaus•
<br />rive but is representative of relevant reliable data.
<br />For more information refer ro product label.
<br />Please wnsuh MonsaMO 'rf further information is
<br />needed.
<br />Folow aO locaVregbnaVne5onal reguleYans.
<br />In this document flte BrHish spelling was applkd.
<br />All iratlemarks herein are trademarks of Monsanto
<br />Company or Os subsidiaries.
<br />Full denomination d most kequenty used acronyms.
<br />OCF (Biocorcenirafion Facrorj, BOO (Biochemical
<br />Oxygen Demand), GOO (Chemical Oxygen Damara),
<br />EC50 (50% effect concentratbn), ED50 (50% effect
<br />tlose), I.M. (intramuscular), I.P. (inUaperkoneel), I.V. '
<br />(intravenous), Koc (So0 atlsorpTan coeHaient), LC50
<br />(50% lethally concentration), LD50 (50% IeMelhy
<br />dose), LDLo (Laver limtt of lethal dosage), LEL (Lower
<br />6cplosion LimS), LOAEC (Lowest Observed Adverse
<br />Efred ConcenUation), LOAEL (Lowest Observed Ad-
<br />verse Effect Level), LOEC (lowest Observed Effect
<br />Concentration), LOEL (Lowest Observed EHed LeveQ,
<br />MEL (Maximum Exposure limit), MTD (Maximum Tot
<br />erated Dose). NOAEC (NO Observed Atlverse EHed
<br />Concentration), NOAEL (No Observed Adverse Ef-
<br />fect Level), NOEC (NO Observed Effect ConceMre-
<br />Hon), NOEL (No Observed EHed Leval), OEL (Occu-
<br />pational Exposure Lim0), PEL (Permissible F~posure
<br />Limo), PII (Primary IrtNation Index), Paw (Padition co-
<br />eRiclenl n-octaraVwaror), S.C. (subcutaneous), STEL
<br />(Shoo-Term Exposure Limit), TLV-C (Thresholtl Umil
<br />Value-GeTng), TLV-TWA (ThreshoM Limit Vatue -Time
<br />Weighted Average), UF1 (Upper Explosion Limk)
<br />This Material Safety Data Sheet (MSDS) serves dtt-
<br />ferent purposes than and DOES~NOT REPLACE OR
<br />MODIFY THE EPA-APPROVED PRODUCT IABEL
<br />ING (attached to and accompanying the product con-
<br />tainer). This MSDS provides important health, safey,
<br />ate.
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