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SAFETY DATA SHEET C LAR I A N T SAFETY DATA SHEET C LAR I A N T <br /> EF NA 078120 Page 12 EF NA 078/20 Page 9 <br /> Substance key:000000854868 Revision Date:09/17/2020 Substance key:000000854868 Revision Date:09/17/2020 <br /> Version:1-0/USA Date of printing:09/17/2020 Version:1-0/USA Date of printing:09/17/2020 <br /> Assessment <br />- GLP:yes <br /> Aspiration toxicity Test Type:Mammalian cell gene mutation assay <br /> Test system:Chinese hamster lung cells <br /> Components: Metabolic activation:with and without metabolic activation <br /> Mercaptobenzothiazole-sodium(MIST-Na): Method:OECD Test Guideline 476 <br /> No aspiration toxicity classification Result:negative <br /> GLP:yes <br /> Difhiophosphate: Germ cell mutagenicity- In vitro tests did not show mutagenic effects <br /> No aspiration toxicity classification Assessment <br /> Experience with human exposure Carcinogenicity <br /> Product Components: <br /> General Information The possible symptoms known are those derived from the Mercaptobenzothiazole-sodium(MBT-Na): <br /> P� YmPt <br /> labelling(see section 2). Species:Rat,(male and female) <br /> Application Route:oral(gavage) <br /> Exposure time:103 wk <br /> SECTION 12.ECOLOGICAL INFORMATION Dose:yes <br /> Frequency of Treatment:5 days/week <br /> Ecotoxicity Subsequent observation period:0,375 or 750 mg/kg bw for mat <br /> LOAEL•188 mg/kg body weight <br /> Components' Method:OECD Test Guideline 451 <br /> Mercaptobenzothiazole-sodium(MBT-Na): <br /> Toxicity,to fish LC50(Oncorhynchus mykiss(rainbow trout)):0.73 mgfl Carcinogenicity- Not classifiable as a human carcinogen. <br /> End point mortality Assessment <br /> Exposure time.96 h <br /> Test Type:flow-through test Dithlophosphate: <br /> Analytical monitoring:yes <br /> Method:OECD Test Guideline 203 Carcinogenicity- No information available. <br /> Assessment <br /> GLP:No information available. <br /> Toxicity to daphnia and other EC50(Daphnia magna(Water flea)):071 mg/I IARC No component of this product present at levels greater than or <br /> aquatic invertebrates End point:Immobilization equal to 0.1%is identified as probable,possible or confirmed <br /> human carcinogen by IARC. <br /> Exposure time:48 h <br /> Analytical monitoring:no data available OSHA No component of this product present at levels greater than or <br /> Method:OECD Test Guideline 202 <br /> GLP:yes equal to 0.1%is on OSHA's list of regulated carcinogens. <br /> Toxicity to algae/aquatic ErC50(Pseudokirchneriella subcapitata(green algae)):0.5 NTP No component of this product present at levels greater than or <br /> plants mg/I equal to 0.1%is identified as a known or anticipated carcinogen <br /> End point:Growth rate by NTP. <br /> Exposure time:72 h <br /> Analytical monitoring:no data available Reproductive toxicity <br /> Method:OECD Test Guideline 201 Components: <br /> GLP:no data available <br /> Mercaptobenzothiazole-sodium(MBT-Na): <br /> Toxicity to fish(Chronic NOEC(Oncorhynchus mykiss(rainbow trout)):0.041 mg/I Effects on fertility Test Type:Two-generation study <br /> toxicity) Exposure time:89 d <br /> Species:Rat,male and female <br /> Test Type:flow-through test Strain:Sprague-Dawley <br /> Analytical monitoring:yes Application Route:oral(feed) <br />