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7773 —3 <br /> SAFETY DATA SHEET C LA R I A N T SAFETY DATA SHEET CLAR I A N T <br /> EF NA 078120 Page 8 EF NA 078120 Page 13 <br /> Substance key:000000854868 Revision Date:09/17/2020 Substance key:000000854868 Revision Date:09/17/2020 <br /> Version:1-0/USA Date of printing:09/17/2020 Version:1-0/USA Date of printing:09/17/2020 <br /> Method:OECD Test Guideline 210 <br /> Germ cell mutagenicity GLP:yes <br /> Components: Toxicity to daphnia and other NOEC(Daphnia magna(Water flea)):0.08 mg/I <br /> Merraptobenzothiazolesodium(MBT-Na): aquatic invertebrates End point Reproduction rate <br /> (Chronic toxicity) Exposure time:21 it <br /> Genotoxicity in vitro Test Type:Ames test Analytical monitoring:no data available <br /> Test system:Salmonella typhimurium Method:OECD Test Guideline 211 <br /> Metabolic activation:with and without metabolic activation GLP:No information available. <br /> Method:Other <br /> Result:negative Toxicity to microorganisms (activated sludge):857 mg/I <br /> GLP:no End point Bacteria toxicity(respiration inhibition) <br /> Exposure time:3 h <br /> Test Type:Chromosome aberration test in vitro Test Type:static test <br /> Test system:Chinese hamster lung cells Analytical monitoring:no <br /> Metabolic activation:with and without metabolic activation Method:ISO 8192 <br /> Method:Other GLP:yes <br /> GLP:no <br /> Remarks:By analogy with a product of similar composition <br /> Ecotoxicology Assessment <br /> Test Type:In vitro gene mutation study in mammalian cells Acute aquatic toxicity Very toxic to aquatic life. <br /> Test system:mouse lymphoma cells <br /> Metabolic activation:with and without metabolic activation Chronic aquatic toxicity Very toxic to aquatic life with long lasting effects. <br /> Method:OECD Test Guideline 476 <br /> Resuft:negative Dithiophosphate: <br /> GLP:no Toxicity to fish LC50(Danio redo(zebra fish)):>791 mg/l <br /> Genotoxicity in vivo Test Type:dominant lethal test <br /> End point:mortality <br /> Species:Rat(male and female) Exposure time:96 h <br /> .. Strain:Sprague-Dawley <br /> Test Type:semi-static test <br /> Application Route:oral(feed) Analytical monitoring:yes <br /> Exposure time:13 wk Method:OECD Test Guideline 203 <br /> Dose:2500,8750,or 15000 ppm GLP:yes <br /> Method:Other <br /> Result:negative Toxicity to daphnia and other EC50(Daphnia magna(Water flea)):>1,020 mgll <br /> GLP:yes aquatic invertebrates End point:Immobilization <br /> Exposure time:48 h <br /> Germ cell mutagenicity- In vivo tests did not show mutagenic effects,In vitro tests did Test Type:static test <br /> Assessment not show mutagenic effects Analytical monitoring:yes <br /> Method:OECD Test Guideline 202 <br /> GLP:yes <br /> Dithiophosphate: <br /> Genotoxicity in vitro Test Type:Ames test Toxicity to algae/aquatic ErC50(Pseudokirchneriella subcapitata(green algae)):267 <br /> Test system:Salmonella typhimurium plants mgfl <br /> Metabolic activation:with and without metabolic activation End point Growth rate <br /> Method:OECD Test Guideline 471 Exposure time:72 h <br /> Result:negative Test Type:static test <br /> GLP:yes Analytical monitoring:yes <br /> Method:OECD Test Guideline 201 <br /> Test Type:Chromosome aberration test in vitro GLP:yes <br /> Test system:Human lymphocytes <br /> Metabolic activation:with and without metabolic activation Toxicity to fish(Chronic Remarks:no data available <br /> Method:OECD Test Guideline 473 toxicity) <br /> Result:negative <br />