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FIRE AND EXPLOSION DATA(continued) <br />. Extinguishing Media Use water on fires near sodium cyanide but minimize amount <br /> of water if containers are opened or burned (see <br /> "Incompatibility" above). Also,judgement should be used in <br /> light of runoff problems (see "Special Fire Fighting <br /> Instructions"below). In some cases it may be desirable to <br /> let a fire burn out by itself. DO NOT use carbon dioxide <br /> (CO2) which reacts with sodium cyanide to produce hydrogen <br /> cyanide if moisture is present. <br /> Special Fire Fighting Instructions Sodium cyanide dissolves readily in water; therefore, <br /> cyanide solution runoff may occur if containers are opened <br /> or burned. Runoff should be contained to avoid <br /> environmental or safety problems. Contained cyanide <br /> solution can be detoxified with hypochlorite. <br /> HEALTH HAZARD INFORMATION <br /> May be fatal if inhaled, swallowed, or absorbed through <br /> skin. Contact with acids or weak alkalies liberates <br /> poisonous gas. Causes eye burns and may irritate skin. <br /> ANIMAL DATA: <br /> oral LD50: 15 mg/kg in rats <br /> The compound is a skin and eye irritant in tests with <br /> laboratory animals. Toxic effects described in animals from <br /> exposure by inhalation, ingestion, or skin contact include <br /> asphyxia (lack of oxygen) , dyspnea (shortness of breath) , <br /> ataxia (incoordination) , tremors, coma, and lethality by <br /> • disrupting oxidative metabolism. Tests in bacterial and <br /> mammalian cell cul—res demonstrate no mutagenic activity. <br /> Tests for embryotc :.city in animals have shown an <br /> esnbryotoxic or te- -ogenic effect only at exposure levels <br /> very nearly letha-'_ t:o the maternal animals. Observance of <br /> the established exposure limits and prevention of skin <br /> contact with sodium cyanide solutions should be adequate to <br /> prevent adverse health effects on anyone in the workplace, <br /> including the conceptus (fetus) . <br /> HUMAN HEALTH EFFECTS: <br /> overexposure by skin contact may include skin irritation <br /> with discomfort and rash. Eye contact may include <br /> irritation or burns with discomfort, tearing or blurring of <br /> vision. Excessive and prolonged contact may result in <br /> permanent eye damage. <br /> Effects of skin contact, inhalation or ingestion <br /> overexposures to cyanide are characterized by central <br /> nervous system excitation followed by depression. Symptoms <br /> may include: <br /> (continued) <br /> 1252CR Page 3 <br />