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#ADDITIONAL INFORMATION AND PEFERENCES(continued) <br /> For most accidental inhalation poisonings, patients are • <br /> revived in a few minutes with complete recovery within 1 to <br /> 2 hours. <br /> If necessary, the patient should be monitored for 24 to 48 <br /> hours. Any patient whose symptoms require the use of IV <br /> antidote should be considered for admittance to an intensive <br /> care unit. <br /> Observe for return of symptoms. Monitor methemoglobin <br /> levels, blood pH and oxy- genation through arterial blood gas <br /> analysis. Calculate a::.ion gap from serum electrolytes; <br /> cyanide poisoning causes lactate accumulation and an anion <br /> gap metabolic acidosis. <br /> Delayed neurotoxic effects are not expected consequences of <br /> cyanide exposure although• these neurotoxic effects may occur <br /> if hypoxia (oxygen defic �ncy) was prolonged or occurred <br /> following massive cyanide exposure. <br /> ADVERSE EFFECTS <br /> Nitrites can produce hypotension through peripheral <br /> vasodilation (widening of the blood vessels) . Methemoglobin <br /> formation, although considered a therapeutic effect, may <br /> cause symptoms if levels exceed 20-30%. Recommended doses <br /> usually produce methemoglobin levels under 20%. Headache, <br /> nausea, vomiting, and syncope -nay follow nitrite <br /> administration. While it is :zportant to be aware of the <br /> effects from nitrite therapy, there have been no <br /> long-lasting effects associated with this treatment regimen <br /> for cyanide exposure in DuPont's experience and knowledge. <br /> CAUTION: <br /> DO NOT USE IN MEDICAL APPLICATIONS INVOLVING PERMANENT <br /> IMPLANTATION IN THE HUMAN BODY. <br /> The data in this Material Safety Data Sheet relates only to the specific material designated herein and <br /> does not relate to use in combination with any other material or in any process. <br /> Responsibility for MSDS: DuPont Chemicals <br /> Engineering & Product Safety <br /> P. O. Box 80709, Chestnut Run <br /> Wilmington, DE 19880-0709 <br /> 302-999-4946 <br /> # Indicates updated section. <br /> End of MSDS <br /> • <br /> 1 R 12 <br />