2008-04-15_REVISION - M1980244 (315)

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TOXICOLOGICAL INFORMATION Animal Data • Sodium Cyanide Oral LD50: 15 mg/kg in-rats Dermal LD50: 11.28-14.63 mg/kg in rabbits Inhalation LC50: no information found but considered to be highly toxic as CN by inhalation Sodium cyanide has not been tested for skin and eye irritation, or for skin sensitization. NOTE: Administration of Sodium cyanide to rats, cats, or dogs by the intravenous or intraperitoneal routes resulted in rapid respiration, confusion, unconsciousness, vomiting, decreased blood pressure, cardiac rate changes, seizures and respiratory failure. Eye: As with other routes of exposure, systemic toxicity and death is possible from contamination of the eye; LD50 dose in rabbits is approximately 5 mg/kg. Sodium cyanide applied to the skin of rabbits produced tremors, retrocolic spasms, convulsions, abnormal breathing patterns, and prostration. Ingestion: Repeated administration of cassava diets containing unspecif ied cyanide ion caused decreased thyroid activity and kidney changes. Long-term administration of 0.5, 1.0, or 2.0 mg/kg/day to dogs produced unspecified acute intoxication symptoms and increased numbers of red blood cells and decreased proteins were observed at doses greater than 1.0 mg/kg/day. Central nervous system changes occurred in all treated dogs. No animal test reports are available to define carcinogenic hazards of Sodium cyanide. Limited reproductive studies do not suggest effects. Some tests have shown the potential for developmental toxicity but only at exposure levels producing toxic effects in the adult animal. Sodium cyanide does not produce genetic damage in bacterial cell cultures, and has not been tested in animals. ECOLOGICAL INFORMATION Ecotoxicological Information Aquatic Toxicity: Sodium Cyanide: 96 hour LC50 - fathead minnows: 0.43-0.66 mg/L 96 hour LC50 - rainbow trout: .046-.075 mg/L 96 hour LC50 - bluegill sunfish: 0.28 mg/L • (Continued) 1252CR Page 13