Laserfiche WebLink
•f',EAiC Antifreeze Page <br />{equivalent to 6.1 g/kg/day} as reduced number of litter, live pups per <br />litter and lie pup weight. No such effects were seen at 1.75% <br />approimatel 3.05 g/kg/da. '1`lte relevance of these ver}~ high dosages <br />to human health is uncertain. Pregnant rats receiving undiluted <br />diethylene glycol by gavage over the period of organogenesis had toxic <br />effects at 4.0 and 8.0 ml/kg/day as mortality, decreased body weight, <br />decreased food consumption increased water consumption and increased <br />lien and kidne weights. Fetotoxicity was seen only at these maternally <br />toic dosages. Decreased fetal body weight occurred at 8.0 ml/kglday, <br />and increased skeletal ariants at 4.0 and 8.0 ml/kg/da. ro embryotixic <br />or teratogenic effects were seen. Neither maternal toxicity nor <br />fetotoicit occurred at 1.0 mUkg/da In a study with mice also <br />receiving undiluted diethyiene glycol over the period of organogenesis, <br />maternal toxicity occurred at 2.5 and 10.0 ml/kg/day, but not at 0.5 <br />mUkg/da. Definitive developmental toxicity was not seen in this <br />species. <br />I2, ECOLOGICAL INFORMATION <br />ENVIRONMENTAL FATE <br />MOVEMENT & PARTITIONING: Biocancentration p~~tential is low <br />less than I00 or og Kow less than 3. Log octanol/water partition <br />coefficient log Kow is 1.36. errs aw onstant is 6.0E 08 aun <br />m3/mol. ioconcentration factor is 10 in golden orfe. <br />DEGRADATIQN & TRANSFORMATION: Biodegradation under <br />aerobic static laboratory conditions is high (BOD20 or BOD28/ThOD <br />greater than 40. 5 Day biochemical oxygen demand (BODS) is 0.78 <br />p/p. 10 a iochemical ogen demand l0 is I.Ofi p/p. 20 Day <br />iocheynical ogee demand 20 is 1.15 p/p. Theoretical oxygen <br />. demand h is calculated toe 1.29 plp. Biodegradation may occur <br />under both aerobic and anaerobic conditions (in either the presence or <br />asence of ogee. Inhibitory concentration (1C50} in OECD <br />"Activated Sludge, Respiration Inhibition Test" (Guideline # 209) is < <br />1000 rng/. Degradation is expected in the atmospheric environment <br />within ties to weeks. <br />ECOTOXICOLOGY: aterial is practical) non toxic to aquatic <br />organisms on an acute basis {LC50 greater than 100 mg/L in most <br />sensitie species. Acute LC50 for fathead minnow (Pimephaies <br />prornelas is 51000 mg/. Acute LC50 for bluegill (Lepomis <br />macrochirus is 27549 mg/. Acute LC50 for rainbow trout <br />ncorhnchus mkiss is aout 18000 46000 mg/. Acute LGSO for <br />gupp Poecilia reticulate is 49300 mg/. Acute LC50 for water flea <br />aphnia magna is 46300 51100 mg/. Acute LC50 for the cladoceran <br />eriodaphn is <br />duia is 10000 25800 mg/. Acute 50 for oafish is 91430 mg/. <br />Acute 50 for rine shrimp Anemia saiina is 20000 mg/. Acute <br />50 for golden orfe euciscus idus is greater than 10000 mgl. Acute <br />50 for goldfish arassius auratus is greater than 5000 mg/. <br />Growth inhibition EC50 for green alga Selenastrum capricornutum is <br />Page 8 of 11 <br />http://www.peakantifreeze.cam/msds/fullforce_msds.html 9/24/01 <br />