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MSD~; -Diesel <br />Sinclair Oil Corporation -August 2440 <br />'~ <br />HAZARDOUS DECOMPOSITTON: <br />Incomplete burning can produce carbon monoxide. , <br />11. TOXICOLOGICAL INFORMATION <br />SYSTEMIC: <br />Petroleum-derived fuels and fuel oils are complex and vaziable mixtures of hydrocarbons. <br />In general; the more viscous the mixture, the less toxic it will be. At high level exposures, <br />humans experience multiple organ failurr_s, some of which may be due to hypoxia and <br />secondary to the failure of other organ systems. In humans kidney failure has been noted <br />only at high, acute levels of exposures, azd appears reversible. Liver enzymes may be <br />transiently elevated. At lower level exposures, most acute health effects are reversible. <br />People can be exposed by inhalation, ingestion and dermal contact. Frequently, people aze <br />exposed by combined dermal and inhalation exposure. <br />ACUTE: <br />inhalation: Headaches, confiuion, disorientation, blurred vision occur with inhalation. <br />Higher exposures may cause hallucinations, CNS excitation, drowsiness, CNS depression. <br />Seizure and coma occur from very high exposures and dea#h may result fmm respiratory <br />depression. ECG changes, cardiac arrhyt:hmias, tachycardia, shock and cardiovascular <br />collapse can occur. Pneumonia, pulrnon~uy edema and hemorrhages can occur. <br />Inhalation of 8044-15440 mg~rn3 for 2 to 4 hours was lethal to rats. <br />ingestian: Central nervous system, cardiovasculaz, and respiratory effects have been <br />reported with acute exposures to various hydrocarbon fuels and oils similar to those <br />reported with inhalation. Nausea, vomiting, cramping and diarrhea mays occur. <br />Eye: Conjunctivitis and burning, watery eyes have been reported in acute exposures to <br />various hydrocarbon fuels and oils. <br />Skin: Mild erythema to full thickness ch~.mical burns have occurred after prolonged <br />exposure to various hydrocarbon fuels and oils. <br />Chronic: <br />Chronic dermatitis with acanthosis; inflammation,, parakeratosis and hyperkeratosis have <br />occurred with chronic exposures to various hydrocarbon fuels and oils. <br />Occupational exposures in petroleum refining are considered Group 2A (probably <br />carcinogenic) by IARC. <br />Patzc 5 of 7 <br />