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<br />5ec[ion 1't. Tvxicnlagi~~l Infarma#4n
<br />ro~idata
<br />f31ES'l:LEXMAU5T FtJMEShav~ beenreported to be a potential acaupa6onal carcinogen in humans byH30SFI Cuneni ntelFgence Sultetin 50.
<br />HEPTANE can atreq;ha body if it is inhaled, comes in contact. Wi(fr the eyes or skin, or is swallowed. Heptane vapor is a narcacic. Concentrations of
<br />f0„D40 to 15,004 ppm produced narr;osis'm mica within 34 ffl fi4 roinutes,.wtrile !5,440 to2D,tktO.ppm caused convulsions and death. At 48,DD4 ppm,
<br />respirarory anesi urns produced in mice in 3 io 4 minutes fmm the staA o! exposure.. Human sut~acts exposed to t„000 pprtrfar 8 rrartutes, note 2,D40
<br />ppm tar # minutas, reparlad slight vertigo. At 5,400 ppm for A minutes,. thorn eras marked vsrtlgo, irtabtlty !o walk a straight Iine, hilarity, and
<br />incaardinatian, Cut na.eearrplainls ofaya and upper respiraiary tract a natcous mert~rane nitation. A t5-minute exposure at 5,004 ppm piaduced In same
<br />subjects a state ofstupor lasting far 34 rreinutes after exposure: Tfiese subjects else reported Ines of appeGk, skght nausea; end a taste resembling
<br />gasaGne far several hours anar exposure. A4hauph chronic nervous aysiem affects have. net men attributed to heptarte, gatynauriiis tree. been rapartad
<br />fallowingptnianged exposure to a petroleum fracgon wife[ ~itingrange_batvveen 7DC and 140C, and This traction would normally wnlain vadousisomers
<br />of heptane as major ingredients.
<br />rh~'fEXAIYE can affect the Cody if leis inhaled; acmes in canlact wi0t the eyes or skin, ar is swallowed. Hexane vapor is a narcotiaand a rmld upper
<br />resprralory irritant Polyneurapattty tperipheral nerve tlamage} has been repcrted to occur in urorkcrs exposed to hexane vapors, characterized CY
<br />peogressive weakness and nurntmess kr the extremities, lass of deep tendon reflexes and radiKaion of mater nerve conduction velocity. Recovery ranges
<br />from no recovery to.campleie~racavery depending upon the duration of exposure and severity of nerve damage. Concentrations of 30,004 ppm produced-
<br />nar~sia in mice vrithin 30 to &6 minutes, canvulsians and dealer occurred at 35,460 to 40.000 ppm, arxt ai$s,060 ppm mspiretary arrest was prodaaed in
<br />2.5 !0 4,5 minutes from the start of exposure. Concentrations up tc 80D0 ppm produced no anesttrasia, In human subjects, 2040 ppm for 10 rrinutes
<br />pmduced ra etfeaEs, but 5004 ppm resulted in rfiztinesa and a sensation of gidraness. Other atvestigators reptsrted.sliglti nausea, headache antl irritation
<br />of Nis eyes and throat at 1400 to 1500 ppm, to industrial prad'nx, mil4 natcoiia symptmrrs sudr as dizzirress-have: bean observed when concentrations
<br />exceeded 9444 ppm, 4ulnot betaw 504 ppm.
<br />NOdYAh1E causes a faun haurLC50 in rats ai cancentratiana a! 3200 ppm,. or et about fire same Eevet es VNI$P Naphifia. phis leveiia markedly lower Oren
<br />the lethal concentrauans rapeReet in eaniermice studies Involving octane (13,544 ppm) and heptane 176,480 ppm}, supporting the fewer fdTal far nanana:
<br />OCTANH rate affect the Cady if it is innated, comas to contaae: with ine skin or eyes or a swmllavued, Octane vapor le a mild narcotic and mucous membrane
<br />rrritanL Concemrahons of fi6D0 to t3,y06 plan produced narcosis in mire in 30 to $(1 minutes, the fatal conaar>ltalion far animals. is Haar d 3,S0D ppm; Na
<br />chrarrac systerrae effects have been reported in hwnans.
<br />NAPMilF1~d.FA1E ran affect the body it it is inhaled, aorrms into contact with the ayes or the skin or H R Is swallowed. Naphthalene v~rar txusas hemotysts
<br />and eye irritation, and trssy cause. cataracts. Severe irrtaxiration fmm ingestion of the soled resutta in cfraractedstic manifesla5ans of~markad intravaswiar
<br />hegnotysrs and its consequences, including potentia ny fatal pyperkalemia. iniEiai ;ymptams include eye irritation., headache, Confu3~n, excitement.
<br />malaise; protusa sw¢aling, nausea, vomiting, abdomrnat pain and irrita!?an ai fete bladder. There may tre prograssicn tb jaundice, hematuria,.
<br />hamoglobkruria, rebel tubular bEaekage, and acute r~nai shutdown. Hamatnlagic features include red aeD fragmentation, icterus, severeanemia. with
<br />nucleated red ceNs, keukocytosis, and dransatic decreases inhemagtobin, tterrratarxit and red cell count: sometimes then: is fomration of Heinz~Cadies and
<br />methemoglabin, Individuals with a deNeiency of glucose-5-phosphate dehydrogenase in erythrocytes. may he mare susceptib3e to hemaiyss by
<br />naptrthatene. CaEararxs and ocular irritation have Coen produced experimentaltyiei animals and have been desan`bed to humans. Of 21 workers exposed
<br />W high concentrel~ns of'tume ar vapor for 5 years, 8 had peripheral tans apaci5es; inother studies, na abnormalities er lid eyes Nava been c~tectesi in
<br />workers exposed !o naphthalene for soveral years. The vapor nausea aye krttatian at 1S ppm. Eyo cameo wish fhe solid may resort rn conf unuivits,
<br />superF•eial injury to the cnmea, chodoretinitis, swtoma, and diminished visual acuity. Naptrthatena an the sk`vr may cause hypersensitivity dermaGfis,
<br />drrania demtatrtis id rare.
<br />HptAf+lE IRS are dtree tirr~s as toxic is rtuie as is pentane. Narmsis was produced in mine. within 34~&D minutes at conaertrations flf 30,OD4 ppm.
<br />In man, conaenirations Ear 74 minutes at 2000 ppm produced no effacta, but 5004 ppm caused diuineas and a sense of gidtlineas. Canoentrafwns at
<br />Sd00-7500 ppm produaad slagh! nau5®a; naadaahe, eye, and tltraa! irritat»n.
<br />EnQrL'dteflt name Test ReSUEt P2oU#e u°jfeCl£S
<br />Naphttlalene LD50 430 mglkg Qra[ Rat
<br />LD50 318 mglkg. Ctrs! Mouse
<br />LC}50 1200 mglkg Ora{ Guinea. pig
<br />LI750 >2500 mg,!kg Dem~al Fiat.
<br />L€3Lo 100 mgfkg dmt diild
<br />L[}Lo a00 mglkg Oral Oog
<br />Chrpnic t>tS gel ttumafts CARCINOGENIC EFF1CTa^. Classified A3 {Proven for animals.} by ACGlH, 3 {Possible
<br />far humans.} by European Unitsn [Diesel fuel]. Classified 3 {Not classifiable far humans.)
<br />by IARC ~[Jiesel PueQ. Classjfied 28 (Possible Par hutnarts~} by IARC (NaphthaleneJ:
<br />Classified A4 (Not rJassiftableforbumans oranimals.) by ACGIH [Naphthalene].
<br />Contains mateiial which causes damage W-the following aygans: blood, kidneys, Fiver,
<br />peripheral nervous system, .upper respiratory tract, skin, central nervous system (CNS},
<br />.eye, lens ar cornea.
<br />Other toxic effects on Very hazardous in wee of eye contact {corrosive}.
<br />humans Hazardous to case of skin cantos {irrilarrt}, of ingest[on, of inhalation {lung irrftartt).
<br />Corrtirttrer! on next gage
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