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To~colo~ and Em~ironmentel Touwlogc 1 1 5 ~ ~ I I 1 ~ '1 I t~ 11.. `` ` / t , ~~ ` ~ ~~. 1 2,4-Dichlorophenoxyacetic Acid Toxicology and Environmental Toxicology http://wwu~.24d.org/tox.h[m I The 1 14 research studies completed in these areas under the EPA reregistration program confirm the ' existing toxicology data package. Apart from the hundreds of unpublished studies required by various regulatory agencies around the world, there are more than 4,000 peer-reviewed, published studies on 2,4-D in the scientific literature. The recent studies reconfirm: • 2,4-D has moderate to low acute toxicity. The LD50 (rats) ranges from 699 mg per kg of body weight (2,4-D acid) to >] 000 mg/kg for ester and amine formulations. From an LD50 standpoint, ' 2,4-D is less toxic than caffeine and slightly more toxic than aspirin. • At the concentrations which may be found in the environment, 2,4-D is highly unlikely to present a threat to wildlife. ' Subchronic effects are generally limited to very high doses when compared to the exposure levels humans may face in the environment. • 2,4-D has low reproductive toxicity. • 2 4-D does not cause birth defects. • Chronic effects are also limited to high doses. • Based on the extensive toxicology, it is highly improbable that 2,4-D causes cancer. ' 2,4-D has low potential to cause neurotoxicity in short and long term exposures. • 2,4-D does not cause genetic damage. Although the publications of many anti-pesticide advocacy groups continue to show 2,4-D to be a mutagen, there are now more than 25 recent, state-of--the-art EPA/GLP mutagenicity studies on 2,4-D in the toxicology data package, none of which show any evidence of mutageniciry. ' Additional information on the Toxicology of 2,4-D is available on the 2.4-D Publication Re. ie~c Site. ' Return to our Home Paue. 12/Ifl/1998 9:58 AM