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~,4-u t oxicotogy ana t:nvironmentat t ox~cotogy rags ~ ui ~ `~. ; ,:,~ ',.I '~ 1 • ~"• ,, ;: ,t~: ~;:~ ,~ n j, .+1 ~; • 2,4-Dichlorophenoxyacetic Acid Toxicology and Environmental Toxicology The 114 reseazch studies completed in these areas under the EPA reregistration program confirm the existing toxicology data package. Apart from the hundreds of unpublished studies required by various regulatory agencies around the world, there aze more than 4,000 peer-reviewed, published studies on 2,4-D in the scientific literature. The recent studies reconfirm: . 2,4-D has moderate to low acute toxicity. The LD50 (rats) ranges from 699 mg per kg of body weight (2,4-D acid) to >1000 mg/kg for ester and amine formulations. From an LD50 standpoint, 2,4-D is less toxic than caffeine and slightly more toxic than aspirin. . At the concentrations which may be found in the environment, 2,4-D is highly unlikely to present a threat to wildlife. . Subchronic effects aze generally limited to very high doses when compared to the exposure levels humans may fice in the environment. . 2,4-D has low reproductive toxicity. . 2,4-D does not cause birth defects. . Chronic effects are also limited to high doses. . Based on the extensive toxicology, it is highly improbable that 2,4-D causes cancer. . 2,4-D has low potential to cause neurotoxicity in short and long term exposures. . 2,4-D does not cause genetic damage. Although the publications of many anti-pesticide advocacy groups continue to show 2,4-D to be a mutagen, there aze now more than 25 recent, state-of--the-art EPA/GLP mutagenicity studies on 2,4-D in the toxicology data package, none of which show any evidence of mutageniciry, Additional information on the Toxicology of 2,4-D is available on the 2,4-D Publication Review Site. Return to our Home Paee. INDUSTRY TASK FORCE II ON 2,4-D RESEARCH DATA B-26 Cedaz Point Villas Swansboro, NC 28584 Information Line: U.S. and Canada (800) 345-5109 http://www.24d.org/toxhtml 11/15/98