Laserfiche WebLink
MONSANTO Material Safety Data <br />ROUNDUP® PRO Herbicide Page 5 of6 <br />MSDS No: 500012732 5/26/99 <br />Skin Irtitation - FIFRA Category IV <br />No skin allergy was observed in guinea pigs following repeated skin exposure. <br />COMPOUNDS: <br />Data from laboratory studies conducted by Monsanto and from the scientific literature on components of <br />ROUNDUP® PRO herbicide: <br />Isopropylamine Salt of Glyphosate: Data from studies with a formulation comprised of 62% isopropylamine salt of <br />glyphosate (MON 0139) indicate the following: <br />In repeat dosing studies (6-month), dogs fed MON 0139 exhibited slight body weight changes. Following repeated <br />skin exposure (3-week) to MON 0139, skin irritation was the primary effect in rabbits. <br />Additional toxicity information is available on glyphosate, the active herbicidal ingredient of MON 0139. Following <br />repeated exposures (90-days) to glyphosate in their feed, decreased weight gains were noted at the highest test level <br />in mice, while no treatment-related effects occurted in rats. Following repeated skin exposure (3 weeks) to <br />glyphosate, slight skin irritation was [he primary effect observed in rabbits. No skin allergy was observed in guinea <br />pigs following repeated skin exposure. There was no evidence of effects on the nervous system, including delayed <br />effects in chickens (repeat oral doses) or cholinesterase inhibition in rats (single oral doses). Reduced body weight <br />gain and effects on liver tissues were observed with long-term (2-year) feeding of glyphosate to mice at high-dose <br />levels. Reduced body weight gain and eye changes were observed at the high-dose level in one long-term (2 year) <br />feeding study with rats, while notreatment-related effects occurred in a second study. No adverse ef7ec[s were <br />observed in feeding studies with dogs. Glyphosate did not produce tumors in any of these studies. Based on the <br />results from the chronic studies, EPA has classified glyphosate in category E (evidence ofnon-carcinogenicity <br />for humans). No birth defects were noted in rats and rabbits given glyphosate orally during pregnancy, even at <br />amounts which produced adverse effects on the mothers. Glyphosate was fed continuously to rats at very high dose <br />levels for 2 successive generations. Toxicity was reported in offspring from the high dose, a level which also <br />produced adverse effects on the mothers. Ina 3 generation study conducted at lower dose levels, no effects were <br />seen on the ability of male or female rats to reproduce. Glyphosate has produced no genetic changes in a variety of <br />standard tests using animals and animal or bacterial cells. <br />12. ECOLOGICAL INFORMATION <br />This product has been tested for toxicity to aquatic invertebrates, fish and birds. The results indicate that [his <br />product is slightly to moderately toxic to D. magna, moderately toxic to warmwater and coldwa[er fish, and <br />practically non-toxic to bobwhite quail and the mallard duck. No data is available regarding algal toxicity for this <br />product. <br />13. DISPOSAL CONSIDERATIONS <br />Wastes resulting from the use of this product that cannot be used or chemically reprocessed should be disposed of in <br />a landfill approved for pesticide disposal or in accordance with applicable Federal, state or local procedures. <br />Emptied container retains vapor and product residue. Observe all labeled safeguards until container is cleaned, <br />reconditioned or destroyed. This product should not be dumped, spilled, rinsed or washed into sewers or public <br />waterways. <br />14. TRANSPORT INFORMATION <br />Follow the precautions indicated in the Handling and Storage Section, Section 7 of this MSDS. <br />