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Mr. Dustin Czapla August 24, 2021 Page 3 1990). Although acute oral doses of cyanide cause cardiovascular,respiratory, and neurophysiological changes, the brain appears to be the organ most sensitive to acute cyanide toxicity (IPCS,2004). Several studies of the acute effects of cyanide in humans, following suicide attempts or accidental poisoning by the oral and inhalation routes, provide additional details, although most such studies include only a limited characterization of exposure. Symptoms of severe cyanide poisoning include vomiting,nausea,weakness,confusion,lethargy,cyanosis,weak and ataxic movements, increased respiratory and heart rates progressing to coma with respiratory depression, seizures, cardiovascular collapse, and death. The principal feature of the acute toxicity profile for cyanide includes lethality by all routes of administration, with a steep rate-dependent dose-response curve. (Id. § 4.1.1 at 18.) These hazards are acknowledged in Applicant's proposed Environmental Protection Plan, which lists the following potential human effects: • Fatal is [sic] swallowed • Fatal in contact with skin • Fatal if inhaled • May cause respiratory damage • May cause drowsiness or dizziness • Causes damage to organs • Causes damages to organs through prolonged or repeated exposure m(Environental Protection Plan Table 21-3.) The Application also affirms that sodium cyanide is "Soluble in water," (id.), meaning it will migrate in groundwater and surface water, and is "Toxic to aquatic organisms." (Id.) Due to the exceptionally high toxicity of cyanide, it is listed as a"hazardous waste"under the Resource Conservation and Recovery Act (6 CCR 100703, Part 261, Appendix V11 (FO07- FO11 wastes) and Appendix V111 (P030 cyanide,and P106 sodium cyanide)) and as an"extremely hazardous substance" under the Emergency Planning and Community Right to Know Act. (40 C.F.R. Part 355, Appendix A.) Cyanide also is a "hazardous substance" under the Clean Water Act (40 C.R.R. § 116.4 (listing hydrogen cyanide, sodium cyanide, and other cyanide compounds)). A chemical as dangerous as cyanide must be handled with the greatest of care and should not be used and disposed of next to residential properties and domestic wells. However,Applicant proposes to use 24 tons of sodium cyanide per month. (Mining Plan at 4-11). Applicant also BURNS FIGA &WILL