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I , <br /> SAFETY DATA SHEET C LA R I AN T SAFETY DATA SHEET C LAR I AN T <br /> EF NA 077/20 Page 12 EF NA 077120 Page 9 <br /> Substance key:SXR025637 Revision Date:09/17/2020 Substance key:SXR025637 Revision Date:09/17/2020 <br /> Version:2-2/USA Date of printing:09/17/2020 Version:2-2/USA Date of printing:09/17/2020 <br /> LOAEL• 124-438 mg/kg Components: <br /> Application Route:oral(feed) <br /> Exposure time:>=70 d Benzothiazole-2-thiol: <br /> Number of exposures:daily Genotoxicity in vitro Test Type:Ames test <br /> Dose:2500-8750-15000 ppm in diet Test system:Salmonella typhimurium <br /> Group:yes Concentration:3-600 jig/plate <br /> Method:Repeated Dose Toxicity(subchronic study) Metabolic activation:with and without metabolic activation <br /> GLP:yes Method:Ames test <br /> Result:negative <br /> Application Route:Inhalation GLP:yes <br /> Remarks:This information is not available. <br /> Test Type:Chromosome aberration test in vitro <br /> Application Route:Skin contact Test system:Chinese hamster lung cells <br /> Remarks:This information is not available. Concentration:0,2-0,6 Yg/ml <br /> Metabolic activation:with and without metabolic activation <br /> Sodium hydroxide: Method:Other <br /> Result:negative <br /> Application Route:Oral <br /> GLP:No information available. <br /> Method:Repeated dose toxicity <br /> Remarks:The study is not necessary from a scientific perspective. Test Type:In vitro gene mutation study in mammalian cells <br /> Application Route:Inhalation Test system:mouse lymphoma cells <br /> PP Concentration:10-100 lig/ml <br /> Method:Repeated dose toxicity Metabolic activation:with and without metabolic activation <br /> Remarks:The study is not necessary from a scientific perspective. Method:OECD Test Guideline 476 <br /> Result:negative <br /> Application Route:Dermal GLP:yes <br /> Method:Repeated dose toxicity <br /> Remarks:The study is not necessary from a scientific perspective. Genotoxicityin vivo Test Type:Micronucleus test <br /> Species:Mouse(male and female) <br /> Aspiration toxicity Strain:CD1 <br /> rrow <br /> Product: Applicaell�fio Route:Bone d ntra Application peritoneal injection <br /> no data available Exposure time:1-2 treatments,<=72 h <br /> Dose:300 mg/kg <br /> Method:Other <br /> Components: Result:negative <br /> Benzothiazole-2-thiol: GLP:yes <br /> No aspiration toxicity classification Germ cell mutagenicity- It is concluded that the product is not mutagenic based on <br /> Assessment evaluation of several mutagenicity tests. <br /> Sodium hydroxide: <br /> Corrosive to the respiratory tract. Sodium hydroxide: <br /> Genotoxicity in vitro Remarks:In vitro tests did not show mutagenic effects <br /> Experience with human exposure Genotoxicity in vivo Remarks:Not classified due to data which are conclusive <br /> Product although insufficient for classification. <br /> General Information The possible symptoms known are those derived from the Germ cell mutagenidty- It is concluded that the product is not mutagenic based on <br /> labelling(see section 2). Assessment evaluation of several mutagenicity tests. <br /> Components: <br /> Carcinogenicity <br /> Sodium hydroxide: <br /> Product: <br />