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__________________________________________________________________________________________________________________________________________________________________________________________11. Toxicological information <br /> 7 of 10 <br />Species rabbit <br />MSDS number 80063 <br />Method OECD 404 <br />Acute oral toxicity <br />Serious eye damage/eye irritation irritant <br />LD50: 2590 mg/kg <br />Species rabbit eye <br />Method OECD 405 <br />Species rat <br />Skin Sensitization nonsensitizer <br />Revision Date Aug.15.2011 <br />Species guinea pig <br />Method OECD 406 <br />Method OECD 401 <br />in vitro Mutagenicity Ames Test: negative - with and without metabolic activation - <br />Method: OECD 471 <br />In vitro Mammalian Chromosome Aberration Test in rat <br />cells: negative - without metabolic activation - Method: <br />OECD 473 <br />Saccharomyces cerevisiae, Gene Mutation Assay: negative <br />with and without metabolic activation - Method: OECD480 <br />Mouse lymphoma cell gene-mutation: negative - with and <br />without metabolic activation - Method: OECD 476 <br />Product name <br />Carcinogenic effects No evidence of carcinogenicity <br />Acute dermal toxicity <br />Reproductive toxicity No toxicity to reproduction <br />(Reference substance: Methyl isobutyl ketone) <br />LD50: 2870 mg/kgRevision Number <br />Routes of exposure inhalation <br />3.02 <br />Species rat <br />Species rabbit <br />Method OECD 416 <br />Methyl isobutyl carbinol <br />NOAEL: 4093 mg/kg bw/day <br />Type of study Two-generation study <br />Method OECD 402 <br />Developmental effects No teratogenetic, maternal or develomental effects <br />Issuing date Mar.02.2012 <br />Routes of exposure Inhalation <br />Acute inhalation toxicity <br />Species rat, and, mouse <br />LC50 (4h): > 16000 mg/m³ <br />Method OECD 414 <br />NOAEL: 4106 mg/kg bw/day <br />Species rat <br />Type of study Prenatal Developmental Toxicity Study <br />AGHS/EN <br />Developmental effects No developmental or reproductive effects (Reference <br />substance: 4-Hydroxy-4-methyl-2-pentanone) <br />Routes of exposure oral gavage <br />Method OECD 403 <br />Species rat <br />SAFETY DATA SHEET <br />Method OECD 422 <br />Skin corrosion/irritation irritating <br />4-Methylpentan-2-ol