2016-07-13_GENERAL DOCUMENTS - M1977493

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REAGENT S-11194 Frother SDS: 0060705 Date Prepared: 07/01/2016 Page 6 of 10 Polymerization: Will not occur Materials To Avoid: Strong oxidizers. 11. TOXICOLOGICAL INFORMATION PRODUCT TOXICITY INFORMATION Likely Routes of Exposure: Oral, Eyes, Skin. ACUTE TOXICITY DATA oral rat Acute LD50 >2000 mg/kg dermal rabbit Acute LD50 >2000 mg/kg inhalation rat Acute LC50 4 hr No data LOCAL EFFECTS ON SKIN AND EYE Acute Irritation skin Irritating Acute Irritation eye Causes serious damage ALLERGIC SENSITIZATION Sensitization skin Sensitizing Sensitization respiratory No data GENOTOXICITY Assays for Gene Mutations Ames Salmonella Assay No data OTHER INFORMATION The product toxicity information above has been estimated. This is a research and development(R&D) sample. The chemical, physical, and toxicological properties of this material have not been fully investigated. Its handling or use may be hazardous. It may only be used for R&D purposes under the supervision of technically qualified individuals. HAZARDOUS INGREDIENT TOXICITY DATA The chemical, physical, and toxicological properties of Alkyl aldehydes have not been fully investigated. Direct contact is expected to cause serious eye damage and moderate skin irritation. Prolonged or repeated contact is expected to cause dermal sensitization. Inhalation exposure of this material may cause irritation to mucous membranes and respiratory tract. 1-Propene, hydroformylation products, high-boiling has acute oral (rat) and acute dermal (rat) LD50 values of>5000 mg/kg and >2000 mg/kg, respectively. Direct contact with this material may produce minimal skin irritation and severe eye irritation. This material did not produce dermal sensitization when tested in guinea pigs. A 28-day repeated dose toxicity study was conducted in male and female rats. The animals were dosed by oral gavage at dose levels of 0, 100, 300 and 1000 mg/kg bw/day. There were no treatment related deaths during the study. The No Observed Adverse Effect Level (NOAEL)for females was considered to be 1000 mg/kg/bw/day as no adverse effects were noted at the highest dose tested. In males, absolute and relative weight decreases in testes accompanied by histopathological changes affecting spermatogenesis were noted; therefore, the No Observed Adverse Effect Level (NOAEL)was considered to be 300 mg/kg/bw/day. This substance is not mutagenic in the Ames Assay, non-genotoxic in the in vitro mammalian cell gene mutation assay and not clastogenic in the in vivo Mouse Micronucleus Assay.