2016-02-16_INSPECTION - C1982056 (2)

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rage j ui i Carcinogenicity: CAS# 67-64-1: Not listed by ACGIH, IARC, NTP, or CA Prop 65. Epidemiology: In a series of studies, no statistically significant differences in causes of death or clinical laboratory results were observed in 948 employees exposed to up to 1070 ppm acetone over 23 years. Teratogenicity: Animal studies have only shown harmful effects in the offspring of animals exposed to doses which also produced significant maternal toxicity. Reproductive Effects: During the Stewart et al. study, four adult female volunteers were exposed 7.5 hours to acetone vapor at a nominal concentration of 1000 ppm.Three of the four women experienced premature menstrual periods which were attributed to the acetone exposure. Mutagenicity: Sex chromosome loss and n ond isju nction (Yeast - Saccharomyces cerevisiae) _ 47600 ppm; Cytogenetic analysis(Rodent - hamster Fibroblast)= 40 gm/L. Neurotoxicity: No information found Other Studies: Section 12 - Ecological Information Ecotoxicity: Fish: Rainbow trout: 5540 mg/l; 96 -hr; LC50Fish: Bluegill/Sunfish: 8300 mg/I; 96 - hr; LC50 No data available. Environmental: Volatilizes, leeches, and biodegrades when released to soil. TERRESTRIAL FATE: If released on soil, acetone will both volatilize and leach into the ground. Acetone readily biodegrades and there is evidence suggesting that it biodegrades fairly rapidly in soils. AQUATIC FATE: If released into water, acetone will probably biodegrade. It is readily biodegradable in screening tests, although data from natural water are lacking. It will also be lost due to volatilization (estimated half-life 20 hr from a model river). Adsorption to sediment should not be significant. Physical: ATMOSPHERIC FATE: In the atmosphere, acetone will be lost by photolysis and reaction with photochemically produced hydroxyl radicals. Half-life estimates from these combined processes are 79 and 13 days in January and June, respectively, for an overall annual average of 22 days. Therefore considerable dispersion should occur. Being miscible in water, wash out by rain should be an important removal process. This process has been confirmed around Lake Shinsei-ko in Japan. There acetone was found in the air and rain as well as the lake. Other: No information available. Section 13 - Disposal Considerations Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification. RCRA P -Series: None listed. RCRA U -Series: CAS# 67-64-1: waste number 0002 (Ignitable waste). Section 14 - Transport Information US DOT Canada TDG http://fscimage.ttshcrsci.com/msds/00I40.htm 2/4/2016