2014-09-18_GENERAL DOCUMENTS - M1977493

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MATERIAL SAFETY DATA SHEET Product Name: TERGITOL(TM) NP-4 SURFACTANT Effective Date: 02/10/2003 MSDS#: 1918 Page 10 of 17 their diet for 90 days did not result in alterations in estrous cycles, sperm measurements, or endocrine organ weights or histopathology. In addition, a three generation (FO through F3 weaning) study conducted by the NIEHS indicated that nonylphenol did not affect reproductive parameters at dietary concentrations up to 2000 ppm in any generation. Effects in juvenile females consistent with those seen in screening assays (e.g., premature vaginal opening)were observed following high level exposure post-weaning (F1, F2, and F3) at 650 and 2000 ppm. Sperm counts were reduced at 650 and 2000 ppm in the F2 adults compared to controls from the same generation. These results and other inconsistent or potentially body weight related findings are considered of questionable significance. The No Observed Adverse Effect Level (NOAEL)for reproduction was 2000 ppm and for all effects was 200 ppm (except as noted for kidneys above). Considering the high doses (e.g., 100-350 mg/kg/day for females in the 2000 ppm group; the higher doses occurring post-weaning), the lack of permanent/prolonged effects is considered significant. Based on the results of these studies, exposure to low doses of nonylphenol, such as from workplace or environmental exposure, would not be expected to result in effects on mammalian reproduction. In a 2-generation reproduction study with octylphenol at dietary concentrations of 0.2 to 2000 ppm, treatment-related effects in adult FO, F1, and F2 animals were limited to reduced body weights and feed consumption at 2000 ppm. No effects on any reproductive parameters were observed in either generation. No effects on sperm measurements, estrous cyclicity, or reproductive organs were observed in adult animals. Pup body weights during lactation were reduced at 2000 ppm. The NOAEL for systemic and postnatal toxicity was 200 ppm (approximately 15 mg/kg/day) and for reproductive toxicity was >2000 ppm (approximately 150 mg/kg/day). Although octylphenol has weak estrogen mimetic activity in some screening assays, no estrogenic or reproductive effects occurred from dietary exposure to rats for two generations over a 10,000 fold dose range. 12. ECOLOGICAL INFORMATION 12.1 ENVIRONMENTAL FATE BOD % Oxygen consumption Day 5 1 Day 10 Day 15 Day 20 Day 28/30 Acclimated 4 % 28 % 1 31 % BOD % Oxygen consumption Day 5 Day 10 Day 15 Day 20 Day 28/30 < 1 % 1 % 1 2 % 4 % Modified Sturm Test OECD 301 B % CO2 evolved Day 5 Day 10 Day 15 Day 28 12.4 % ��Modified Sturm Test (OECD 301B)(% CO2 evolved)