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Material Safety Data Sheet <br />Material Name: Aluminum Sulfate <br />Distributed by: Rocky Mountain Reagents, Inc <br />Part Number: A1055 ID: C1 -166 <br />* * * Section 11 - Toxicological Information <br />Acute Toxicity <br />A: General Product Information <br />Severely irritating or corrosive to the skin, eyes and gastrointestinal tract. Prolonged exposure to the skin may cause numbing <br />effects. Product can cause severe irritation and inflammation of the eyes. Concentrated solutions may cause permanent damage to <br />eyes or skin, or blindness. Dusts of this product form sulfuric acid when in contact with moisture in air or tissues. Inhalation of <br />dust or mist is irritating to respiratory tract and mouth. Symptoms of irritation may include coughing, congestion and sore throat. <br />High concentrations may cause constriction of the airways. Ingestion may cause burns to the mouth, throat and stomach. <br />Symptoms may include vomiting, nausea, bleeding stomach, and abdominal pain. Soluble aluminum compounds can be absorbed <br />from the gut, and excess levels can be deposited in bone. Once absorbed, aluminum is eliminated rapidly by the kidneys, unless <br />renal failure is present. Repeated ingestion of this product can weaken bones by phosphate deficiency. Ingestion of large amounts <br />of Aluminum Sulfate by humans has resulted in death. Lethality by ingestion is probably due to the corrosive action of the <br />sulfuric acid formed by the hydrolysis of the salt. Ingestion of small amounts of aluminum sulfate may cause a sensation of <br />dryness in the mucous membranes of the mouth and throat. <br />B: Component Analysis - LD50ILC50 <br />Aluminum Sulfate (10043 -01 -3) <br />LD50 ( Unreported -Rat) 410 mg/kg; LD50 (Oral- Mouse) 6207 mg/kg; LD50 (Intraperitoneal- Mouse) 274 mg/kg; LD50 (Unreported - <br />Mouse) 520 mg/kg; LD50 (Unreported - Guinea Pig) 490 mg/kg <br />B: Component Analysis - TDLo /LDLo <br />Aluminum Sulfate (10043 -01 -3) <br />TDLo (Oral -Rat) 10138 mg/kg/8 days- continuous: Kidney, Ureter, Bladder: other changes in urine composition; Nutritional and <br />Gross Metabolic: changes in phosphorus; TDLo (Intraperitoneal- Mouse) 800 mg/kg: female 10 -13 day(s) after conception: <br />Reproductive: Effects on Newborn: growth statistics (e.g. %, reduced weight gain) Reproductive: Effects on Newborn: <br />behavioral; TDLo (Intratesticular -Rat) 27371 µg/kg: male 1 day(s) pre - mating: Reproductive: Paternal Effects: spermatogenesis <br />(incl. genetic material, sperm morphology, motility, and count), testes, epididymis, sperm duct; TDLo (Subcutaneous- Mouse) <br />27371 pg/kg: male 30 day(s) pre - mating: Reproductive: Paternal Effects: spermatogenesis (incl. genetic material, sperm <br />morphology, motility, and count), testes, epididymis, sperm duct <br />Carcinogenicity <br />A: General Product Information <br />Information not available. <br />B: Component Carcinogenicity <br />This compound is not listed by ACGIH, EPA, IARC, OSHA, NIOSH, or NTP. <br />Epidemiology <br />Information not available. <br />Neurotoxicity <br />With extensive exposures, aluminum may accumulate in brain tissue producing neurotoxicity, including encephalopathy and <br />seizures (based on animal data). <br />Mutagenicity <br />A solution of Aluminum Sulfate in water produced positive results in cultured human cells (leukolytes), via sister chromatid <br />exchanges, micronuclei and chromosomal aberrations). Negative results have been obtained in bacteria and cultured mammalian <br />cells. <br />Teratogenicity <br />In 88 women exposed during pregnancy to excessive Aluminum Sulfate levels in drinking water, the outcome of pregnancy, fetal <br />viability and birth weight parameters were normal compared to unexposed controls. The only significant difference found in the <br />infants of exposed mothers was an increase in skeletal malformations of the foot. <br />Other Toxicological Information <br />On occasion workers chronically exposed to aluminum- containing dusts or fumes have developed severe pulmonary reactions <br />including fibrosis, emphysema and pneumothorax. A much rarer encephalopathy has also been described. The factors which <br />predispose to lung damage are not well characterized. <br />Issue Date: 4/27/99 08:45:30 CLW Page 5 of 8 Revision Date: 01/04/08 12:30 pm HDF <br />