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<br />Some current reqistration activity <br /> <br />The USFWS is presently screening drugs and chemicals for possible use in <br />fisheries. Other agencies and chemical companies are also actively involved. <br />Status on some products are as follows: <br /> <br />1) Ch10ramine-T. For control of bacterial gill disease. <br /> <br />a) Research is progressing well. <br />b) Not toxic to mammals. <br />c) Efficacy and toxicity work completed. <br />d) FDA registration should be obtained within 1 or 2 years. <br /> <br />2) Huamine 3500, Benzalkonium chloride and related compounds. For control of <br />bacterial gill diseases. <br /> <br />a) Problems developed in clearance work because analysis methods are very <br />difficult and costly (several hundred dollars cost per analysis). <br />b) Clearance work will be discontinued in order to concentrate on <br />registration of chloramine-To <br /> <br />3) Oxolinic acid. For control of bacterial diseases. <br /> <br />a) Appears to be a very effective drug against furunculosis, enteric <br />redmouth and vibriosis. <br />b) Being used in Europe now. <br /> <br />4) Iodophores (Betadine, Wescondyne, etc.). <br /> <br />a) For externally disinfecting fish eggs against bacterial and viral <br />diseases - effective. <br />b) The FDA indicated no problems as these chemicals are being used <br />presently. <br />c) Iodophores have also been found safe for water-hardening sa1monid eggs. <br />Active iodine concentrations ranged from 15-300 ppm over various <br />exposure times and circumstances without causing toxicity (Anonymous <br />1987) . <br /> <br />5) 17-a-methyltestosterone. A masculinity hormone. <br /> <br />a) The FDA does not appear to be concerned with present fishery use. <br />b) The FDA is now studying on how to proceed with any regulation with all <br />hormones. <br /> <br />ACKNOWLEDGEMENTS <br /> <br />My literature review and fact-finding task was greatly enhanced and <br />simpl ified when I found one very significant publ ication by Rosa1 ie A. Schnick <br />and Fred P. Meyer, USFWS, National Fishery Research Laboratory, La Crosse, <br /> <br />22 <br />