Laserfiche WebLink
trimethyltins were usually not reversible. Triethyltins were also toxic to <br />small mammals, but effects--which were similar to those of trimethyltins--were <br />usually reversible after cessation of exposure. <br />All evidence to date indicates that organotin compounds are not <br />carcinogenic. <br />Methodologies and data necessary for the promulgation of effective <br />criteria and standards to protect natural resources seem to be deficient in <br />eight key areas: (1) routine analytical chemical methodologies for extraction, <br />separation, and identification of inorganic and organic tin compounds and <br />their chemical speciation products in biological and other samples; (2) <br />mechanisms of toxicity for organotin compounds; (3) rates of uptake, <br />retention, and translocation of organotins in biota; (4) persistence and <br />mobility rates of organotins in nonbiological materials; (5) rates of tin <br />methylation and biotransformation in biological and abiotic samples; (6) <br />organotin interactions with other toxic chemicals; (7) quantitative structure <br />activity relation for use in evaluating organotin toxicity; and (8) long-term <br />environmental monitoring studies in terrestrial and aquatic ecosystems for <br />establishment of baseline concentrations. <br />iv