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dose depen?Snt manner (Lee et al. 1986b). In ?B earlier study (Lee et al. <br />1985), As was about 1OX more potent than As in effecting transformation?5 <br />The birth defects were most pronounced in golden hamsters exposed to As <br />during the 24-hour period of critical+gmbryogenesis--i.e., day 8 of gestation <br />(Ferm and Hanlon 1985)--when 1.7 mg As /kg body weight induced neural tube <br />defects in about 90% of the fetuses. Hanlon and Ferm (1986a) showed that <br />hamsters exposed to As and heat stress (39 C for 50 minutes) on day 8 of <br />gestation produced a greater+5percentage of malformed offspring (18 to 39%) <br />than did hamsters exposed to As alone (4% to 8%). <br />TERRESTRIAL PLANTS AND INVERTEBRATES <br />In general, arsenic availability to plants is highest in coarse-textured <br />soils having little colloidal material and little ion exchange capacity, and <br />lowest in fine-textured soils high in clay, organic material, iron, calcium, <br />and phosphate (NRCC 1978). To be absorbed by plants, arsenic compounds must <br />be in a mobile form in the soil solution. Except for locations where arsenic <br />content is high, e.g., around smelters, the accumulated arsenic is distributed <br />throughout the plant body in nontoxic amounts (NAS 1977). For most plants, a <br />significant depression in crop yields was evident at soil-As concentrations of <br />3 to 28 mg/l of water soluble arsenic and 25 to 85 mg/kg of total arsenic <br />(NRCC 1978). Yields of peas (Pisum sativum), a sensitive species, were <br />decreased at 1 mg/l of water soluble arsenic or 25 mg/kg of total soil As; <br />rice (Oryza sativum) yields were decreased 75% at 50 mg/l of disodium <br />methylarsonate in silty loam; and soybeans (G1 cine max) grew poorly when <br />residues exceeded 1 mg As/kg (Table 3; NRCC 1978). Forage plants grown in <br />soils contaminated with up to 80 mg total As/kg from arsenical orchard sprays <br />contained up to 5.8 mg As/kg dry weight; however, these plants were considered <br />nonhazardous to grazing ruminants (Merry et al. 1986). <br />Attention was focused on inorganic arsenical pesticides after <br />accumulations of arsenic in soils eventually became toxic to several <br />agricultural crops, especially on former orchards and cotton fields. Once <br />toxicity is observed, it persists for several years even if no additional <br />arsenic treatment is made (Woolson 1975). Poor crop growth was associated <br />with bioavailability of arsenic in soils. For example, alfalfa (Medicago <br />sativa) and barley (Hordeum vul are) grew poorly in soils containing only 3.4 <br />to 9.5 mg As/kg, provided the soils were acidic, lightly textured, low in <br />phosphorus and aluminum, high in iron and calcium, and contained excess <br />moisture (Woolson 1975). Use of inorganic arsenical herbicides, such as <br />calcium arsenate, to golf course turfs for control of fungal blight sometimes <br />exacerbates the disease. The use of arsenicals on Kentucky bluegrass (Poa <br />pratensis) is discouraged under conditions of high moisture and root stress <br />induced by previous arsenical applications (Smiley et al. 1985). <br />39